Abstract

The Administrative Core oversees and guides the operation of the COBRE on Mechanisms of Liver Injury and Diseases at the University of Kansas Medical Center. The Program Director/Principal Investigator will be Dr. Hartmut Jaeschke, who was the PD/PI during Phase II. He will be assisted and advised by the Program Coordinator Dr. Bruno Hagenbuch and other members of the Steering Committee consisting of the chairs of the 2 cores, the Pilot Grants Program Director, and the Senior Associate Dean for Research of the School of Medicine. An External Advisory Board comprised of five internationally recognized authorities in liver research will also provide guidance and advice for the COBRE operation and will function as external reviewers for the Pilot Grants Program. The Administrative Core will oversee and guide the highly successful Core Laboratories and the Pilot Grants Program in addition to providing continued mentoring and career development guidance for junior faculty.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
1P30GM118247-01
Application #
9073978
Study Section
Special Emphasis Panel (ZGM1-RCB-3 (C3))
Project Start
Project End
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
1
Fiscal Year
2016
Total Cost
$279,624
Indirect Cost
$96,863

  Institution

Name
University of Kansas
Department
Type
DUNS #
016060860
City
Kansas City
State
KS
Country
United States
Zip Code
66160

  Publications

Boxberger, Kelli H; Hagenbuch, Bruno; Lampe, Jed N (2018) Ligand-dependent modulation of hOCT1 transport reveals discrete ligand binding sites within the substrate translocation channel. Biochem Pharmacol 156:371-384
Adams, Abby; Weinman, Steven A; Wozniak, Ann L (2018) Caspase-1 regulates cellular trafficking via cleavage of the Rab7 adaptor protein RILP. Biochem Biophys Res Commun 503:2619-2624
Wu, Raymond; Murali, Ramachandran; Kabe, Yasuaki et al. (2018) Baicalein Targets GTPase-Mediated Autophagy to Eliminate Liver Tumor-Initiating Stem Cell-Like Cells Resistant to mTORC1 Inhibition. Hepatology 68:1726-1740
Borude, Prachi; Bhushan, Bharat; Apte, Udayan (2018) DNA Damage Response Regulates Initiation of Liver Regeneration Following Acetaminophen Overdose. Gene Expr 18:115-123
Li, Jibiao; Woolbright, Benjamin L; Zhao, Wen et al. (2018) Sortilin 1 Loss-of-Function Protects Against Cholestatic Liver Injury by Attenuating Hepatic Bile Acid Accumulation in Bile Duct Ligated Mice. Toxicol Sci 161:34-47
Woolbright, Benjamin L; Jaeschke, Hartmut (2018) Mechanisms of Inflammatory Liver Injury and Drug-Induced Hepatotoxicity. Curr Pharmacol Rep 4:346-357
Zou, An; Magee, Nancy; Deng, Fengyan et al. (2018) Hepatocyte nuclear receptor SHP suppresses inflammation and fibrosis in a mouse model of nonalcoholic steatohepatitis. J Biol Chem 293:8656-8671
Ramachandran, Anup; Jaeschke, Hartmut (2018) Acetaminophen Toxicity: Novel Insights Into Mechanisms and Future Perspectives. Gene Expr 18:19-30
Ramachandran, Anup; Jaeschke, Hartmut (2018) Oxidative Stress and Acute Hepatic Injury. Curr Opin Toxicol 7:17-21
Li, Yuan; Chao, Xiaojuan; Yang, Li et al. (2018) Impaired Fasting-Induced Adaptive Lipid Droplet Biogenesis in Liver-Specific Atg5-Deficient Mouse Liver Is Mediated by Persistent Nuclear Factor-Like 2 Activation. Am J Pathol 188:1833-1846

Showing the most recent 10 out of 65 publications