Abstract

The Administrative Core oversees and guides the operation of the COBRE on Mechanisms of Liver Injury and Diseases at the University of Kansas Medical Center. The Program Director/Principal Investigator will be Dr. Hartmut Jaeschke, who was the PD/PI during Phase II. He will be assisted and advised by the Program Coordinator Dr. Bruno Hagenbuch and other members of the Steering Committee consisting of the chairs of the 2 cores, the Pilot Grants Program Director, and the Senior Associate Dean for Research of the School of Medicine. An External Advisory Board comprised of five internationally recognized authorities in liver research will also provide guidance and advice for the COBRE operation and will function as external reviewers for the Pilot Grants Program. The Administrative Core will oversee and guide the highly successful Core Laboratories and the Pilot Grants Program in addition to providing continued mentoring and career development guidance for junior faculty.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
1P30GM118247-01
Application #
9073978
Study Section
Special Emphasis Panel (ZGM1-RCB-3 (C3))
Project Start
Project End
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
1
Fiscal Year
2016
Total Cost
$279,624
Indirect Cost
$96,863

  Institution

Name
University of Kansas
Department
Type
DUNS #
016060860
City
Kansas City
State
KS
Country
United States
Zip Code
66160

  Publications

Wang, Shaogui; Wang, Hua; Ding, Wen-Xing (2018) Pyroptosis, A novel player for alcoholic hepatitis? Hepatology 67:1660-1662
Funk, Ryan S; Singh, Rakesh K; Winefield, Robert D et al. (2018) Variability in Potency Among Commercial Preparations of Berberine. J Diet Suppl 15:343-351
Du, Kuo; Ramachandran, Anup; Weemhoff, James L et al. (2018) Mito-tempo protects against acute liver injury but induces limited secondary apoptosis during the late phase of acetaminophen hepatotoxicity. Arch Toxicol :
Woolbright, Benjamin L; Jaeschke, Hartmut (2018) Is Keratin-18 only a Marker of Cell Death in Acute-On-Chronic Liver Failure? J Lab Precis Med 3:
McGreal, Steven R; Bhushan, Bharat; Walesky, Chad et al. (2018) Modulation of O-GlcNAc Levels in the Liver Impacts Acetaminophen-Induced Liver Injury by Affecting Protein Adduct Formation and Glutathione Synthesis. Toxicol Sci 162:599-610
Zhao, Jie; Adams, Abby; Roberts, Ben et al. (2018) Protein arginine methyl transferase 1- and Jumonji C domain-containing protein 6-dependent arginine methylation regulate hepatocyte nuclear factor 4 alpha expression and hepatocyte proliferation in mice. Hepatology 67:1109-1126
Jaeschke, Hartmut; Duan, Luqi; Akakpo, Jephte Y et al. (2018) The role of apoptosis in acetaminophen hepatotoxicity. Food Chem Toxicol 118:709-718
Jaeschke, Hartmut (2018) Mechanisms of sterile inflammation in acetaminophen hepatotoxicity. Cell Mol Immunol 15:74-75
Wang, Yifeng; Li, Jibiao; Matye, David et al. (2018) Bile acids regulate cysteine catabolism and glutathione regeneration to modulate hepatic sensitivity to oxidative injury. JCI Insight 3:
Jaeschke, Hartmut; Ramachandran, Anup (2018) Oxidant Stress and Lipid Peroxidation in Acetaminophen Hepatotoxicity. React Oxyg Species (Apex) 5:145-158

Showing the most recent 10 out of 65 publications