- User Training and Outreach The User Training and Outreach component of the ALS-ENABLE Resource ensures that users have the training and information to incorporate ALS-ENABLE technologies directly and immediately into their research efforts. This is accomplished through individual and broad-based training of users on the operations and best practices of data collection at ALS-ENABLE beamlines. While direct interactions are emphasized, a host of online materials are provided to help researchers succeed in their goals. Workshops and seminars will train large groups at once and our unique ?reverse? synchrotron trip provides training at the NIH user's home institution. Outreach activities are a key component of informing the scientific community of the capabilities, availability, and modes of access to the ALS-ENABLE Resource. We will publish results, present ALS- ENABLE specific materials at scientific meetings, and host seminars and workshops on Resource technologies. Specific efforts will be made to engage and recruit projects from scientists that may not use structural biology as their main technique. A robust web presence will support these efforts and provide access to all beamine manuals, training materials, scientific highlights, and descriptions of the technologies available through the different ALS-ENABLE Cores. Eventually, the ALS-ENABLE web site will provide one-stop access and guidance through the ALS General User proposal process through integration with ALS-Hub system.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Center Core Grants (P30)
Project #
1P30GM124169-01
Application #
9370117
Study Section
Special Emphasis Panel (ZRG1)
Project Start
Project End
Budget Start
2017-09-01
Budget End
2018-07-31
Support Year
1
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Lawrence Berkeley National Laboratory
Department
Type
DUNS #
078576738
City
Berkeley
State
CA
Country
United States
Zip Code
94720
Hjortness, Michael K; Riccardi, Laura; Hongdusit, Akarawin et al. (2018) Abietane-Type Diterpenoids Inhibit Protein Tyrosine Phosphatases by Stabilizing an Inactive Enzyme Conformation. Biochemistry 57:5886-5896
Ogorzalek, Tadeusz L; Hura, Greg L; Belsom, Adam et al. (2018) Small angle X-ray scattering and cross-linking for data assisted protein structure prediction in CASP 12 with prospects for improved accuracy. Proteins 86 Suppl 1:202-214
Criglar, Jeanette M; Anish, Ramakrishnan; Hu, Liya et al. (2018) Phosphorylation cascade regulates the formation and maturation of rotaviral replication factories. Proc Natl Acad Sci U S A 115:E12015-E12023
Blaisse, Michael R; Fu, Beverly; Chang, Michelle C Y (2018) Structural and Biochemical Studies of Substrate Selectivity in Ascaris suum Thiolases. Biochemistry 57:3155-3166
Hu, Liya; Sankaran, Banumathi; Laucirica, Daniel R et al. (2018) Glycan recognition in globally dominant human rotaviruses. Nat Commun 9:2631
Guo, Hou-Fu; Tsai, Chi-Lin; Terajima, Masahiko et al. (2018) Pro-metastatic collagen lysyl hydroxylase dimer assemblies stabilized by Fe2+-binding. Nat Commun 9:512
Chang, Aram; Abderemane-Ali, Fayal; Hura, Greg L et al. (2018) A Calmodulin C-Lobe Ca2+-Dependent Switch Governs Kv7 Channel Function. Neuron 97:836-852.e6
Patel, Meha P; Hu, Liya; Brown, Cameron A et al. (2018) Synergistic effects of functionally distinct substitutions in ?-lactamase variants shed light on the evolution of bacterial drug resistance. J Biol Chem 293:17971-17984
Qin, Liying; Sankaran, Banumathi; Aminzai, Sahar et al. (2018) Structural basis for selective inhibition of human PKG I? by the balanol-like compound N46. J Biol Chem 293:10985-10992
Kern, Jan; Chatterjee, Ruchira; Young, Iris D et al. (2018) Structures of the intermediates of Kok's photosynthetic water oxidation clock. Nature 563:421-425

Showing the most recent 10 out of 18 publications