The Rose F. Kennedy Center for Research in Mental Retardation and Human Development conducts basic and clinical research on the normal and aberrant development of the nervous system and on factors that influence neurological and cognitive function. The Kennedy Center is founded on the principal that the strength and cohesiveness of the overall research program depend on the excellence of the individual investigators and their ability to develop and maintain strong collaborative research efforts directed to the mission of the MRRCs. Center research programs are focused in four main areas: Molecular and Developmental Neurobiology; Systems and Cognitive Neuroscience; Pathobiology of Developmental and Degenerative Brain Disorders; and Normal and Aberrant Human Neurobehavioral Development. The staffing of the Center is multidisciplinary, with representation from ten basic science and clinical departments of the College of Medicine. The multidisciplinary composition of the faculty reflects the philosophic commitment of the Center to a broad-based program designed to translate basic research findings into clinical applications and ultimately therapeutic intervention. The Clinical Facilities of the Center include the Children's Evaluation and Rehabilitation Center, which forms the focus of the Center's University Affiliated Program (UAP). Several research and clinical training programs in neuroscience and in mental retardation and developmental disabilities are based at the Center. The Kennedy Center provides a large number of critical core services to Center investigators in nine Core facilities. The scientific and administrative support provided by these facilities not only enhances the scientific capabilities and excellence of the Center -investigators, but also leads to substantial cost savings because of shared usage. The overall impact of the Center Program is to attract researchers to mental retardation research and to foster basic and clinical investigations in this area.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
5P30HD001799-34
Application #
2673357
Study Section
Mental Retardation Research Committee (HDMR)
Project Start
1977-09-01
Project End
2000-07-31
Budget Start
1998-08-01
Budget End
1999-07-31
Support Year
34
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Albert Einstein College of Medicine
Department
Miscellaneous
Type
Schools of Medicine
DUNS #
009095365
City
Bronx
State
NY
Country
United States
Zip Code
10461
Qureshi, Irfan A; Mehler, Mark F (2014) Epigenetic mechanisms underlying the pathogenesis of neurogenetic diseases. Neurotherapeutics 11:708-20
Qureshi, Irfan A; Mehler, Mark F (2014) Epigenetics of sleep and chronobiology. Curr Neurol Neurosci Rep 14:432
Qureshi, Irfan A; Mehler, Mark F (2014) An evolving view of epigenetic complexity in the brain. Philos Trans R Soc Lond B Biol Sci 369:
Qureshi, Irfan A; Mehler, Mark F (2014) Sex, epilepsy, and epigenetics. Neurobiol Dis 72 Pt B:210-6
Nguyen, Giang D; Gokhan, Solen; Molero, Aldrin E et al. (2014) The role of H1 linker histone subtypes in preserving the fidelity of elaboration of mesendodermal and neuroectodermal lineages during embryonic development. PLoS One 9:e96858
Qureshi, Irfan A; Mehler, Mark F (2013) Epigenetic mechanisms governing the process of neurodegeneration. Mol Aspects Med 34:875-82
Qureshi, Irfan A; Mehler, Mark F (2012) Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease. Nat Rev Neurosci 13:528-41
Nalavadi, Vijayalaxmi C; Muddashetty, Ravi S; Gross, Christina et al. (2012) Dephosphorylation-induced ubiquitination and degradation of FMRP in dendrites: a role in immediate early mGluR-stimulated translation. J Neurosci 32:2582-7
Qureshi, Irfan A; Mehler, Mark F (2011) Non-coding RNA networks underlying cognitive disorders across the lifespan. Trends Mol Med 17:337-46
Qureshi, Irfan A; Mehler, Mark F (2011) Alu transcription: a rheostat for stem cell aging? Cell Cycle 10:3820-1

Showing the most recent 10 out of 19 publications