Abstract

The Genetics Core provides services for MRRC investigators who engage in genetics research related to mental retardation and developmental disabilities. The Genetics Core includes (1) A tissue culture laboratory which maintains cell lines from patients with many genetic disorders and is directed by Dr. Ronald Scott. (2) A glassware preparation facility which provides sterile, RNase free glass were among other services. (3) A molecular genetics equipment and consultation service directed by Dr. Philip Mirkes and Dr. Christopher Wilson. The research areas served by this Core include gene mapping, gene regulation, immunology, and teratology. Daily Core activities are managed by Dr. Tom Cotner, who serves as the coordinator for the Core, and two technicians. Main equipment of the Core includes laminar flow hoods and a large liquid nitrogen storage system for cell lines, large dry and wet autoclaves, X-ray developer, automated DNA sequencer, an ultraviolet cross-linker, a thermocycler, and drying ovens. The Core is located in several separate areas of the MRRC Medical Research Unit.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
5P30HD002274-35
Application #
6630009
Study Section
Project Start
2002-07-01
Project End
2003-06-30
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
35
Fiscal Year
2002
Total Cost
$88,647
Indirect Cost

  Institution

Name
University of Washington
Department
Type
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Shelton, Annie L; Wang, Jun Y; Fourie, Emily et al. (2018) Middle Cerebellar Peduncle Width-A Novel MRI Biomarker for FXTAS? Front Neurosci 12:379
Peeples, Eric S; Ezeokeke, Chikodinaka K; Juul, Sandra E et al. (2018) Evaluating a Targeted Bedside Measure of Cerebral Perfusion in a Nonhuman Primate Model of Neonatal Hypoxic-Ischemic Encephalopathy. J Ultrasound Med 37:913-920
Mitchell, Timothy; MacDonald, James W; Srinouanpranchanh, Sengkeo et al. (2018) Evidence of cardiac involvement in the fetal inflammatory response syndrome: disruption of gene networks programming cardiac development in nonhuman primates. Am J Obstet Gynecol 218:438.e1-438.e16
Hasegawa, Yu; Curtis, Britni; Yutuc, Vernon et al. (2018) Microbial structure and function in infant and juvenile rhesus macaques are primarily affected by age, not vaccination status. Sci Rep 8:15867
Klusek, Jessica; Porter, Anna; Abbeduto, Leonard et al. (2018) Curvilinear Association Between Language Disfluency and FMR1 CGG Repeat Size Across the Normal, Intermediate, and Premutation Range. Front Genet 9:344
Shickman, Ryan; Famula, Jessica; Tassone, Flora et al. (2018) Age- and CGG repeat-related slowing of manual movement in fragile X carriers: A prodrome of fragile X-associated tremor ataxia syndrome? Mov Disord 33:628-636
Zhou, Vanessa; Munson, Jeffrey A; Greenson, Jessica et al. (2017) An exploratory longitudinal study of social and language outcomes in children with autism in bilingual home environments. Autism :1362361317743251
Klusek, Jessica; LaFauci, Giuseppe; Adayev, Tatyana et al. (2017) Reduced vagal tone in women with the FMR1 premutation is associated with FMR1 mRNA but not depression or anxiety. J Neurodev Disord 9:16
Boland, Michael J; Nazor, Kristopher L; Tran, Ha T et al. (2017) Molecular analyses of neurogenic defects in a human pluripotent stem cell model of fragile X syndrome. Brain 140:582-598
Choi, Won-Seok; Kim, Hyung-Wook; Tronche, François et al. (2017) Conditional deletion of Ndufs4 in dopaminergic neurons promotes Parkinson's disease-like non-motor symptoms without loss of dopamine neurons. Sci Rep 7:44989

Showing the most recent 10 out of 276 publications