Abstract

The University of Washington's Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center (IDDRC), based at the Center on Human Development and Disability (CHDD), provides a comprehensive interdisciplinary research program in the field of intellectual/developmental disabilities and related aspects of human development. Research is carried out in three major domains: (1) Developmental and Molecular Genetics, (2) Developmental Neuroscience, and (3) Developmental Processes and Behavioral Science. Interdisciplinary collaborations are emphasized in research carried out in 12 Research Emphasis Areas;Autism, Craniofacial Malformations, Developmental Toxicology, Ecological Factors, Fetal Alcohol Syndrome, Fragile X Syndrome, Infectious Disease and Immunology, Joubert Syndrome, Learning Disabilities, Neurodegenerative Disorders, Neurodevelopmental Oncology, and Neuroinflammation. Through this grant mechanism, support is requested for six scientific core facilities and one administrative core to enhance the effectiveness of scientists carrying out their research as part of the IDDRC. The scientific core support facilities are as follows: (1) Genetics, (2) Brain Imaging, (3) Cellular Morphology, (4) Behavioral Science, (5) Infant Primate Research Laboratory, and (6) Instrument Development Laboratory. Other IDDRC objectives include training researchers in various disciplines, disseminating research findings, and maintaining linkages to clinical training activities and exemplary service programs.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
5P30HD002274-46
Application #
8508964
Study Section
Special Emphasis Panel (ZHD1-MRG-C (16))
Program Officer
Parisi, Melissa
Project Start
1989-08-01
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
46
Fiscal Year
2013
Total Cost
$1,619,901
Indirect Cost
$581,503

  Institution

Name
University of Washington
Department
Type
Organized Research Units
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Shelton, Annie L; Wang, Jun Y; Fourie, Emily et al. (2018) Middle Cerebellar Peduncle Width-A Novel MRI Biomarker for FXTAS? Front Neurosci 12:379
Peeples, Eric S; Ezeokeke, Chikodinaka K; Juul, Sandra E et al. (2018) Evaluating a Targeted Bedside Measure of Cerebral Perfusion in a Nonhuman Primate Model of Neonatal Hypoxic-Ischemic Encephalopathy. J Ultrasound Med 37:913-920
Mitchell, Timothy; MacDonald, James W; Srinouanpranchanh, Sengkeo et al. (2018) Evidence of cardiac involvement in the fetal inflammatory response syndrome: disruption of gene networks programming cardiac development in nonhuman primates. Am J Obstet Gynecol 218:438.e1-438.e16
Hasegawa, Yu; Curtis, Britni; Yutuc, Vernon et al. (2018) Microbial structure and function in infant and juvenile rhesus macaques are primarily affected by age, not vaccination status. Sci Rep 8:15867
Klusek, Jessica; Porter, Anna; Abbeduto, Leonard et al. (2018) Curvilinear Association Between Language Disfluency and FMR1 CGG Repeat Size Across the Normal, Intermediate, and Premutation Range. Front Genet 9:344
Shickman, Ryan; Famula, Jessica; Tassone, Flora et al. (2018) Age- and CGG repeat-related slowing of manual movement in fragile X carriers: A prodrome of fragile X-associated tremor ataxia syndrome? Mov Disord 33:628-636
Zhou, Vanessa; Munson, Jeffrey A; Greenson, Jessica et al. (2017) An exploratory longitudinal study of social and language outcomes in children with autism in bilingual home environments. Autism :1362361317743251
Klusek, Jessica; LaFauci, Giuseppe; Adayev, Tatyana et al. (2017) Reduced vagal tone in women with the FMR1 premutation is associated with FMR1 mRNA but not depression or anxiety. J Neurodev Disord 9:16
Boland, Michael J; Nazor, Kristopher L; Tran, Ha T et al. (2017) Molecular analyses of neurogenic defects in a human pluripotent stem cell model of fragile X syndrome. Brain 140:582-598
Choi, Won-Seok; Kim, Hyung-Wook; Tronche, François et al. (2017) Conditional deletion of Ndufs4 in dopaminergic neurons promotes Parkinson's disease-like non-motor symptoms without loss of dopamine neurons. Sci Rep 7:44989

Showing the most recent 10 out of 276 publications