Abstract

This proposal provides central support for Research in Mental Retardation at UCLA. The Mental Retardation Research Center at UCLA is a multi-funded, interdisciplinary research and teaching program which has the following objectives: 1. Research into problems of mental retardation and related aspects of human development. 2. Research training, at the pre- and post-doctoral levels, of specialists in a variety of disciplines related to our goals. Studies fall into the following categories: Developmental Biology, Neurophysiology, Neurobiochemistry and Socio-Behavioral Research. Most of our research efforts are carried out on the UCLA campus. Additionally, a large multi-disciplinary research program exists at the Pacific State Hospital (recently re-named Lanterman State Hospital) in Pomona, California.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
5P30HD004612-19
Application #
3102789
Study Section
Mental Retardation Research and Training Committee (HDMR)
Project Start
1978-06-01
Project End
1990-07-31
Budget Start
1987-06-01
Budget End
1990-07-31
Support Year
19
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
University of California Los Angeles
Department
Type
Hospitals
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095

  Publications

Van, Christina; Condro, Michael C; Lov, Kenny et al. (2018) PACAP/PAC1 Regulation of Inflammation via Catecholaminergic Neurons in a Model of Multiple Sclerosis. J Mol Neurosci :
Ago, Yukio; Hayata-Takano, Atsuko; Kawanai, Takuya et al. (2017) Impaired extinction of cued fear memory and abnormal dendritic morphology in the prelimbic and infralimbic cortices in VPAC2 receptor (VIPR2)-deficient mice. Neurobiol Learn Mem 145:222-231
Yvone, Griselda M; Zhao-Fleming, Hannah H; Udeochu, Joe C et al. (2017) Disabled-1 dorsal horn spinal cord neurons co-express Lmx1b and function in nociceptive circuits. Eur J Neurosci 45:733-747
Krityakiarana, Warin; Zhao, Paul M; Nguyen, Kevin et al. (2016) Proof-of Concept that an Acute Trophic Factors Intervention After Spinal Cord Injury Provides an Adequate Niche for Neuroprotection, Recruitment of Nestin-Expressing Progenitors and Regeneration. Neurochem Res 41:431-49
Espinosa-Jeffrey, Araceli; Blanchi, Bruno; Biancotti, Juan Carlos et al. (2016) Efficient Generation of Viral and Integration-Free Human Induced Pluripotent Stem Cell-Derived Oligodendrocytes. Curr Protoc Stem Cell Biol 38:2D.18.1-2D.18.27
Condro, Michael C; Matynia, Anna; Foster, Nicholas N et al. (2016) High-resolution characterization of a PACAP-EGFP transgenic mouse model for mapping PACAP-expressing neurons. J Comp Neurol 524:3827-3848
Espinosa-Jeffrey, Araceli; Nguyen, Kevin; Kumar, Shalini et al. (2016) Simulated microgravity enhances oligodendrocyte mitochondrial function and lipid metabolism. J Neurosci Res 94:1434-1450
Krityakiarana, Warin; Zhao, Paul M; Nguyen, Kevin et al. (2016) Erratum to: Proof-of Concept that an Acute Trophic Factors Intervention After Spinal Cord Injury Provides an Adequate Niche for Neuroprotection, Recruitment of Nestin-Expressing Progenitors and Regeneration. Neurochem Res 41:1844
Abad, Catalina; Jayaram, Bhavaani; Becquet, Laurine et al. (2016) VPAC1 receptor (Vipr1)-deficient mice exhibit ameliorated experimental autoimmune encephalomyelitis, with specific deficits in the effector stage. J Neuroinflammation 13:169
Khankan, Rana R; Griffis, Khris G; Haggerty-Skeans, James R et al. (2016) Olfactory Ensheathing Cell Transplantation after a Complete Spinal Cord Transection Mediates Neuroprotective and Immunomodulatory Mechanisms to Facilitate Regeneration. J Neurosci 36:6269-86

Showing the most recent 10 out of 82 publications