Abstract

The San Antonio Center for Research in Reproductive Biology is a multidisciplinary research effort, oriented to the development of new alternative methods of contraception. We are investigating reproductive mechanisms at several levels, including: neuroendocrine control of ovulation; hormone-receptor-chromatin interactions in breast, oviduct, and uterus; regulation of tubal transport; and control of male reproduction. Our definitive objective is utilization of the information acquired to design innovative methods of contraception. Eight senior scientists form the Research Program Committee of the Center. Each supervises the activities of less established investigators within his area of special competence. Nineteen scientists are involved in the Center. The applicant institution has demonstrated, by past and present actions, a strong commitment to research and training in population-related fields.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
2P30HD010202-11
Application #
3102895
Study Section
Population Research and Training Committee (HDPR)
Project Start
1977-09-01
Project End
1992-08-31
Budget Start
1987-09-01
Budget End
1988-08-31
Support Year
11
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
University of Texas Health Science Center San Antonio
Department
Type
Schools of Medicine
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229

  Publications

King, T S; McNichol, M; Canez, M S et al. (2001) Effect of acute administration of cocaine on pituitary gonadotrophin secretion in female rats. Reproduction 122:723-9
Siler-Khodr, T M; Kang, I S; Koong, M K et al. (1997) The effect of dexamethasone on CRH and prostanoid production from human term placenta. Prostaglandins 54:639-53
Siler-Khodr, T M; Kang, I S; Koong, M K (1996) Dose-related action of estradiol on placental prostanoid prediction. Prostaglandins 51:387-401
Siler-Khodr, T M; Forman, J; Sorem, K A (1995) Dose-related effect of IGF-I on placental prostanoid release. Prostaglandins 49:1-14
Schenker, S; Yang, Y; Johnson, R F et al. (1993) The transfer of cocaine and its metabolites across the term human placenta. Clin Pharmacol Ther 53:329-39
Kang, I S; Siler-Khodr, T M (1993) Effect of exogenous arachidonic acid and enzyme inhibitors on placental prostanoid production. Placenta 14:341-53
King, T S; Canez, M S; Gaskill, S et al. (1993) Chronic cocaine disruption of estrous cyclicity in the rat: dose-dependent effects. J Pharmacol Exp Ther 264:29-34
Siler-Khodr, T M; Forman, J (1993) Effect of IGF-1 on placental prostanoid production. Prostaglandins 46:361-70
Espey, L L; Tanaka, N; Stacy, S et al. (1992) Inhibition of ovulation in the gonadotropin-primed immature rat by exogenous prostaglandin E2. Prostaglandins 43:67-74
King, T S; Kang, I S; Javors, M A et al. (1992) Phorbol esters stimulate in vitro GnRH release from the hypothalamus of the estrogen-primed, ovariectomized rat: inhibitory effects of cocaine. Neuroendocrinology 56:526-32

Showing the most recent 10 out of 118 publications