Abstract

This is an application for support of core facilities in the Reproductive Biology and Behavior unit, Oregon Regional Primate Research Center, Beaverton. This unit comprises 19 members with multidisciplinary approaches to the study of primate reproduction. Areas of active research include: neuroendocrine events influencing the hypophyseal-gonadal axis; steroid hormone mechanisms in the brain and reproductive tract; control of sperm motility; immunoreproductive pathophysiology; neural and endocrine changes during aging; and endocrine physiology of the menstrual cycle and pregnancy. Support is requested for the following core laboratories (a) radioimmunoassay and bioassay, (b) morphology, (c) cell culture and monoclonal antibodies, and (d) administration. The existence of these facilities will enhance collaboration among members of the unit and prevent unnecessary duplication.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
5P30HD018185-03
Application #
3102938
Study Section
Population Research and Training Committee (HDPR)
Project Start
1984-09-01
Project End
1989-08-31
Budget Start
1986-09-01
Budget End
1987-08-31
Support Year
3
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
Oregon Regional Primate Research Center
Department
Type
DUNS #
City
Beaverton
State
OR
Country
United States
Zip Code
97006

  Publications

Bethea, C L; Reddy, A P (2015) Ovarian steroids regulate gene expression related to DNA repair and neurodegenerative diseases in serotonin neurons of macaques. Mol Psychiatry 20:1565-78
Rivera, H M; Bethea, C L (2012) Ovarian steroids increase spinogenetic proteins in the macaque dorsal raphe. Neuroscience 208:27-40
Dissen, G A; Lomniczi, A; Boudreau, R L et al. (2012) Targeted gene silencing to induce permanent sterility. Reprod Domest Anim 47 Suppl 4:228-32
Tachibana, Masahito; Sparman, Michelle; Ramsey, Cathy et al. (2012) Generation of chimeric rhesus monkeys. Cell 148:285-95
Lee, Hyo-Sang; Ma, Hong; Juanes, Rita Cervera et al. (2012) Rapid mitochondrial DNA segregation in primate preimplantation embryos precedes somatic and germline bottleneck. Cell Rep 1:506-15
Tachibana, Masahito; Ma, Hong; Sparman, Michelle L et al. (2012) X-chromosome inactivation in monkey embryos and pluripotent stem cells. Dev Biol 371:146-55
Sorwell, Krystina G; Kohama, Steven G; Urbanski, Henryk F (2012) Perimenopausal regulation of steroidogenesis in the nonhuman primate. Neurobiol Aging 33:1487.e1-13
Dorfman, Mauricio D; Kerr, Bredford; Garcia-Rudaz, Cecilia et al. (2011) Neurotrophins acting via TRKB receptors activate the JAGGED1-NOTCH2 cell-cell communication pathway to facilitate early ovarian development. Endocrinology 152:5005-16
Garcia-Rudaz, Cecilia; Dorfman, Mauricio; Nagalla, Srinivasa et al. (2011) Excessive ovarian production of nerve growth factor elicits granulosa cell apoptosis by setting in motion a tumor necrosis factor ?/stathmin-mediated death signaling pathway. Reproduction 142:319-31
Adams Waldorf, K M; Rubens, C E; Gravett, M G (2011) Use of nonhuman primate models to investigate mechanisms of infection-associated preterm birth. BJOG 118:136-44

Showing the most recent 10 out of 96 publications