Abstract

The objective of the Biostatistics Core is to help Center investigators make quantitative inferences by consulting and collaborating on research related to reproduction. The Core provides experimental design, data management and data analysis in support of approved projects in the Center. Core personnel also develop and implement novel Biostatistical techniques that are necessary to improve the analysis of data collected by Center investigators. Examples of such Biostatistical techniques include: improved estimation of hormone levels in sera from assays, including radioimmunoassays; development of models to identify pulses in hormone secretion from a series of samples; and development of a method to identify seasonal peaks and troughs in a series of LH samples from sheep. Members of this Core will develop additional biostatistical methods in collaboration with approved Center investigators.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
2P30HD018258-14
Application #
6240950
Study Section
Project Start
1997-04-01
Project End
1998-03-31
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
14
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Type
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Mahoney, Megan M; Rossi, Brooke V; Hagenauer, Megan H et al. (2011) Characterization of the estrous cycle in Octodon degus. Biol Reprod 84:664-71
Tsuneta, Taeko; Loch-Caruso, Rita; Quensen 3rd, John F et al. (2008) Stimulatory effects of a microbially dechlorinated polychlorinated biphenyl (PCB) mixture on rat uterine contraction in vitro. Environ Res 107:185-93
Caruso, Rita Loch; Upham, Brad L; Harris, Craig et al. (2005) Biphasic lindane-induced oxidation of glutathione and inhibition of gap junctions in myometrial cells. Toxicol Sci 86:417-26
Loch-Caruso, Rita; Upham, Brad L; Harris, Craig et al. (2005) Divergent roles for glutathione in lindane-induced acute and delayed-onset inhibition of rat myometrial gap junctions. Toxicol Sci 85:694-702
Billings, Heather J; Viguie, Catherine; Karsch, Fred J et al. (2002) Temporal requirements of thyroid hormones for seasonal changes in LH secretion. Endocrinology 143:2618-25
Viguie, C; Jansen, H T; Glass, J D et al. (2001) Potential for polysialylated form of neural cell adhesion molecule-mediated neuroplasticity within the gonadotropin-releasing hormone neurosecretory system of the ewe. Endocrinology 142:1317-24
Olson, K K; Anderson, L E; Wiltbank, M C et al. (2001) Actions of prostaglandin F2alpha and prolactin on intercellular adhesion molecule-1 expression and monocyte/macrophage accumulation in the rat corpus luteum. Biol Reprod 64:890-7
Wang, C T; Peters-Golden, M; Loch-Caruso, R (2001) A calcium-independent phospholipase activity insensitive to bromoenol lactone mediates arachidonic acid release by lindane in rat myometrial cells. Life Sci 70:453-70
Krieger, T R; Loch-Caruso, R (2001) Antioxidants prevent gamma-hexachlorocyclohexane-induced inhibition of rat myometrial gap junctions and contractions. Biol Reprod 64:537-47
Bae, J; Mousa, M A; Quensen 3rd, J F et al. (2001) Stimulation of contraction of pregnant rat uterus in vitro by non-dechlorinated and microbially dechlorinated mixtures of polychlorinated biphenyls. Environ Health Perspect 109:275-82

Showing the most recent 10 out of 201 publications