Abstract

This program-project requests CORE and implementation support for a broadly based program for the study of mental retardation and related aspects of human development. The scientific base for the program rests upon investigation in three major areas: (a) Genetics and Metabolism; (b) Neuroscience; (c) Behavioral Science; all converging on a fourth area, (d) Clinical Studies of the Human Subject. The methodological and philosophical approaches include the clinical disciplines of pediatrics, neurology, neurosurgery, radiology, psychiatry, psychology, ophthalmology, otology and the basic science disciplines of pathology, physiology, pharmacology and biochemistry. The program is housed in five floors of the Pediatric Sciences Building. The objective of the program is to provide a scientific and clinical base for the better understanding of the factors leading to mental retardation and to apply this information to prevention of the disorder, and management of the mentally handicapped individual.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
5P30HD018655-08
Application #
3102971
Study Section
Mental Retardation Research Committee (HDMR)
Project Start
1983-01-01
Project End
1991-12-31
Budget Start
1990-01-01
Budget End
1990-12-31
Support Year
8
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Leviton, Alan; Allred, Elizabeth N; Fichorova, Raina N et al. (2018) Circulating biomarkers in extremely preterm infants associated with ultrasound indicators of brain damage. Eur J Paediatr Neurol 22:440-450
van der Burg, Jelske W; O'Shea, T Michael; Kuban, Karl et al. (2018) Are Extremely Low Gestational Age Newborns Born to Obese Women at Increased Risk of Cerebral Palsy at 2 Years? J Child Neurol 33:216-224
Joyal, Jean-Sébastien; Gantner, Marin L; Smith, Lois E H (2018) Retinal energy demands control vascular supply of the retina in development and disease: The role of neuronal lipid and glucose metabolism. Prog Retin Eye Res 64:131-156
Robinson, Shenandoah; Corbett, Christopher J; Winer, Jesse L et al. (2018) Neonatal erythropoietin mitigates impaired gait, social interaction and diffusion tensor imaging abnormalities in a rat model of prenatal brain injury. Exp Neurol 302:1-13
O'Shea, Thomas M; Joseph, Robert M; Allred, Elizabeth N et al. (2018) Accuracy of the Bayley-II mental development index at 2 years as a predictor of cognitive impairment at school age among children born extremely preterm. J Perinatol 38:908-916
Liu, Yuanyuan; Latremoliere, Alban; Li, Xinjian et al. (2018) Touch and tactile neuropathic pain sensitivity are set by corticospinal projections. Nature 561:547-550
Chen, Bo; Li, Yi; Yu, Bin et al. (2018) Reactivation of Dormant Relay Pathways in Injured Spinal Cord by KCC2 Manipulations. Cell 174:521-535.e13
Ci, Yanpeng; Li, Xiaoning; Chen, Maorong et al. (2018) SCF?-TRCP E3 ubiquitin ligase targets the tumor suppressor ZNRF3 for ubiquitination and degradation. Protein Cell 9:879-889
Sieker, Jakob T; Proffen, Benedikt L; Waller, Kimberly A et al. (2018) Transcriptional profiling of articular cartilage in a porcine model of early post-traumatic osteoarthritis. J Orthop Res 36:318-329
Leviton, Alan; Allred, Elizabeth N; Joseph, Robert M et al. (2018) Behavioural dysfunctions of 10-year-old children born extremely preterm associated with corticotropin-releasing hormone expression in the placenta. Acta Paediatr 107:1932-1936

Showing the most recent 10 out of 1442 publications