This Center Grant requests CORE and implementation support for a broadly based program for the study of Mental Retardation and Developmental Disabilities. The scientific basis of the research program rests upon investigation in two major program areas: a) Genetics and b) Neuroscience - Biological Neurogenetics, Developmental Neurology, Cellular Neuroscience, Developmental Neurology, Epilepsy Studies, Ophthalmology. Additional closely related laboratories: Developmental Biology and Endocrinology have been established. Clinical and Behavioral Research is centered in three additional laboratories, i.e., Neuroepidemiology, Clinical Neurophysiology/Behavior, and Neuropsychology and a new program of neonatal neurology clinical research is planned. The multidisciplinary approaches include fields of pediatrics, neurology, neurosurgery, neuropathology, psychiatry and ophthalmology, and the relevant basic science fields of genetics and the various neurosciences. The laboratory program is housed in over 50,000 square feet of the Enders Pediatric Sciences Building. The objective of the program is to provide a scientific and clinical basis for the better understanding of the factors leading to Mental Retardation and Developmental Disabilities, and to apply this information to the prevention of these disorders, and to the management of the handicapped individual.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
5P30HD018655-13
Application #
2197699
Study Section
Mental Retardation Research Committee (HDMR)
Project Start
1983-01-01
Project End
1996-07-31
Budget Start
1994-08-01
Budget End
1995-07-31
Support Year
13
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
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Korzeniewski, Steven J; Allred, Elizabeth N; O'Shea, T Michael et al. (2018) Elevated protein concentrations in newborn blood and the risks of autism spectrum disorder, and of social impairment, at age 10 years among infants born before the 28th week of gestation. Transl Psychiatry 8:115
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van der Burg, Jelske W; O'Shea, T Michael; Kuban, Karl et al. (2018) Are Extremely Low Gestational Age Newborns Born to Obese Women at Increased Risk of Cerebral Palsy at 2 Years? J Child Neurol 33:216-224
Joyal, Jean-Sébastien; Gantner, Marin L; Smith, Lois E H (2018) Retinal energy demands control vascular supply of the retina in development and disease: The role of neuronal lipid and glucose metabolism. Prog Retin Eye Res 64:131-156
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