1. ADMINISTRATIVE CORE (CORE A) 1.a. OBJECTIVE The overall objective of the Administrative Core is to facilitate the mission of the MRDDRC. Thus, the goals of the Administrative Core are to ensure that 1) the research in this Center is focused on problems of relevance and importance to mental retardation and developmental disabilities, 2) the research is organized around clearly-defined themes, 3) the research is of the highest scientific merit, 4) there is facilitation of multidisciplinary research and research training, 5) translation of basic research findings to clinical application is a high priority, and 6) there is fostering of """"""""centerness"""""""", that leads to synergistic interactions between MRDDRC investigators. We believe that the activities outlined throughout this grant (see Progress Report, Core Descriptions, and Research Projects Proposed for Core Usage) demonstrate that we are achieving these goals, and it is our intention to continue to strive to build upon our previous successes during the next funding period. We propose an organizational structure that will provide scientific/programmatic leadership and crucial day-today administrative/managerial support to MRDDRC investigators. We discuss below these two features of the Administrative Core under """"""""Services Provided"""""""" (Section 1.5).

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
5P30HD018655-29
Application #
8137226
Study Section
Special Emphasis Panel (ZHD1)
Project Start
Project End
Budget Start
2010-07-01
Budget End
2011-06-30
Support Year
29
Fiscal Year
2010
Total Cost
$426,900
Indirect Cost
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
Sieker, Jakob T; Proffen, Benedikt L; Waller, Kimberly A et al. (2018) Transcriptional profiling of synovium in a porcine model of early post-traumatic osteoarthritis. J Orthop Res :
Waber, Deborah P; Bryce, Cyralene P; Girard, Jonathan M et al. (2018) Parental history of moderate to severe infantile malnutrition is associated with cognitive deficits in their adult offspring. Nutr Neurosci 21:195-201
Leviton, Alan; Dammann, Olaf; Allred, Elizabeth N et al. (2018) Neonatal systemic inflammation and the risk of low scores on measures of reading and mathematics achievement at age 10 years among children born extremely preterm. Int J Dev Neurosci 66:45-53
O'Connell, Amy E; Zhou, Fanny; Shah, Manasvi S et al. (2018) Neonatal-Onset Chronic Diarrhea Caused by Homozygous Nonsense WNT2B Mutations. Am J Hum Genet 103:131-137
Hirschberger, Rachel G; Kuban, Karl C K; O'Shea, Thomas M et al. (2018) Co-occurrence and Severity of Neurodevelopmental Burden (Cognitive Impairment, Cerebral Palsy, Autism Spectrum Disorder, and Epilepsy) at Age Ten Years in Children Born Extremely Preterm. Pediatr Neurol 79:45-52
Korzeniewski, Steven J; Allred, Elizabeth N; O'Shea, T Michael et al. (2018) Elevated protein concentrations in newborn blood and the risks of autism spectrum disorder, and of social impairment, at age 10 years among infants born before the 28th week of gestation. Transl Psychiatry 8:115
Sveinsdóttir, Kristbjörg; Ley, David; Hövel, Holger et al. (2018) Relation of Retinopathy of Prematurity to Brain Volumes at Term Equivalent Age and Developmental Outcome at 2 Years of Corrected Age in Very Preterm Infants. Neonatology 114:46-52
Gilles, Floyd; Gressens, Pierre; Dammann, Olaf et al. (2018) Hypoxia-ischemia is not an antecedent of most preterm brain damage: the illusion of validity. Dev Med Child Neurol 60:120-125
Laprairie, Robert B; Petr, Geraldine T; Sun, Yan et al. (2018) Huntington's disease pattern of transcriptional dysregulation in the absence of mutant huntingtin is produced by knockout of neuronal GLT-1. Neurochem Int :
Kambara, Tracy K; Ramsey, Kathryn M; Dove, Simon L (2018) Pervasive Targeting of Nascent Transcripts by Hfq. Cell Rep 23:1543-1552

Showing the most recent 10 out of 1442 publications