Abstract

The NICHD Population Research Core Grant operates within the Laboratories for Reproductive Biology to promote interdisciplinary research on the control of reproduction leading to better methods for contraception and for treatment of reproductive disorders. Major emphasis has been placed on the male. A broad range of research centering on molecular mechanisms regulating male reproductive functions has been brought together in The Laboratories for Reproductive Biology within the areas of reproductive neuroendocrinology, regulation of gonadal function, sperm maturation, fertilization and implantation. The shared Core Facilities included in the P-30 population center provide recombinant DNA, tissue culture, histochemistry-microscopy, radioimmunoassay, peptide synthesis/sequencing, transgenic mouse, and administrative services. In addition to enhancing the productivity, quality and cost effectiveness of research, the Cores nurture interdisciplinary collaboration among reproductive scientists and facilitate technical training within The Laboratories for Reproductive Biology. Eligibility for core use is requested for 33 funded research projects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
5P30HD018968-11
Application #
2197746
Study Section
Population Research Committee (HDPR)
Project Start
1984-08-01
Project End
1997-03-31
Budget Start
1994-04-01
Budget End
1995-03-31
Support Year
11
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Pediatrics
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Halpern, Carolyn Tucker; Campbell, Benjamin; Agnew, Christopher R et al. (2002) Associations between stress reactivity and sexual and nonsexual risk taking in young adult human males. Horm Behav 42:387-98
Kim, Desok; Gregory, Christopher W; French, Frank S et al. (2002) Androgen receptor expression and cellular proliferation during transition from androgen-dependent to recurrent growth after castration in the CWR22 prostate cancer xenograft. Am J Pathol 160:219-26
Gregory, C W; Kim, D; Ye, P et al. (1999) Androgen receptor up-regulates insulin-like growth factor binding protein-5 (IGFBP-5) expression in a human prostate cancer xenograft. Endocrinology 140:2372-81
Kim, D; Gregory, C W; Smith, G J et al. (1999) Immunohistochemical quantitation of androgen receptor expression using color video image analysis. Cytometry 35:2-10
Fenstermacher, D A; Joseph, D R (1998) Analysis of promoter and androgen regulatory sequences required for optimal transcription of the rat androgen-binding protein gene. J Androl 19:81-91
Choong, C S; Kemppainen, J A; Wilson, E M (1998) Evolution of the primate androgen receptor: a structural basis for disease. J Mol Evol 47:334-42
Halpern, C T; Udry, J R; Suchindran, C (1998) Monthly measures of salivary testosterone predict sexual activity in adolescent males. Arch Sex Behav 27:445-65
Eddy, E M; O'Brien, D A (1998) Gene expression during mammalian meiosis. Curr Top Dev Biol 37:141-200
Gregory, C W; Hamil, K G; Kim, D et al. (1998) Androgen receptor expression in androgen-independent prostate cancer is associated with increased expression of androgen-regulated genes. Cancer Res 58:5718-24
Langley, E; Kemppainen, J A; Wilson, E M (1998) Intermolecular NH2-/carboxyl-terminal interactions in androgen receptor dimerization revealed by mutations that cause androgen insensitivity. J Biol Chem 273:92-101

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