Abstract

Investigators from the Kennedy Krieger Institute (KKI), the McKusick-Nathans Institute of Genetic Medicine (IGM) and The Johns Hopkins University School of Medicine (JHUSOM) utilize the Genetics Core of the MRDDRC (MRDD-GC) as a resource in their efforts to better understand the role of genetic factors associated with normal and abnormal physical, cognitive and/or behavioral development. The MRDD-GC has been part of the MRDDRC since its inception in 1988. Since that time developments in the fields of genetics and molecular biology have occurred that have literally revolutionized the biomedical research enterprise. Most visibly, the Human Genome Project had not yet started in 1988, and its findings, as well as the technoligies that have emerged for conducting genome-wide studies, have had immense impacts. As the following Core description will illustrate, our capabilities and programs of supported reseach have kept abreast of these developments, and we have maintained state-of-the-science facilities and expertise throughout these recent decades of rapid scientific advances and technological achievements.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
3P30HD024061-25S1
Application #
8743405
Study Section
Special Emphasis Panel (ZHD1-MRG-C)
Project Start
1997-08-01
Project End
2014-06-30
Budget Start
2013-09-28
Budget End
2014-06-30
Support Year
25
Fiscal Year
2013
Total Cost
$31,263
Indirect Cost
$11,917

  Institution

Name
Hugo W. Moser Research Institute Kennedy Krieger
Department
Type
DUNS #
155342439
City
Baltimore
State
MD
Country
United States
Zip Code
21205

  Publications

Sweda, Romy; Phillips, Andre W; Marx, Joel et al. (2016) Glial-Restricted Precursors Protect Neonatal Brain Slices from Hypoxic-Ischemic Cell Death Without Direct Tissue Contact. Stem Cells Dev 25:975-85
Jenkins, Edmund C; Ye, Lingling; Krinsky-McHale, Sharon J et al. (2016) Telomere longitudinal shortening as a biomarker for dementia status of adults with Down syndrome. Am J Med Genet B Neuropsychiatr Genet 171B:169-74
Schneider, Heather E; Lam, Janet C; Mahone, E Mark (2016) Sleep disturbance and neuropsychological function in young children with ADHD. Child Neuropsychol 22:493-506
Reinblatt, Shauna P; Leoutsakos, Jeannie-Marie S; Mahone, E Mark et al. (2015) Association between binge eating and attention-deficit/hyperactivity disorder in two pediatric community mental health clinics. Int J Eat Disord 48:505-11
Gaddis, Andrew; Rosch, Keri S; Dirlikov, Benjamin et al. (2015) Motor overflow in children with attention-deficit/hyperactivity disorder is associated with decreased extent of neural activation in the motor cortex. Psychiatry Res 233:488-95
Porambo, Michael; Phillips, Andre W; Marx, Joel et al. (2015) Transplanted glial restricted precursor cells improve neurobehavioral and neuropathological outcomes in a mouse model of neonatal white matter injury despite limited cell survival. Glia 63:452-65
Diehl, Adam; Mu, Weiyi; Batista, Denise et al. (2015) An atypical 0.73 MB microduplication of 22q11.21 and a novel SALL4 missense mutation associated with thumb agenesis and radioulnar synostosis. Am J Med Genet A 167:1644-9
Koriakin, Taylor A; Mahone, E Mark; Jacobson, Lisa A (2015) Sleep Difficulties are Associated with Parent Report of Sluggish Cognitive Tempo. J Dev Behav Pediatr 36:717-23
Reinblatt, Shauna P; Mahone, E Mark; Tanofsky-Kraff, Marian et al. (2015) Pediatric loss of control eating syndrome: Association with attention-deficit/hyperactivity disorder and impulsivity. Int J Eat Disord 48:580-8
Walsh, D M; Doran, E; Silverman, W et al. (2015) Rapid assessment of cognitive function in down syndrome across intellectual level and dementia status. J Intellect Disabil Res 59:1071-9

Showing the most recent 10 out of 376 publications