Abstract

This Special Mental Health-Clinical Research Center renewal application requests funding for infra-structure which supports a program of research on the classification and course of the schizophrenias. Schizophrenia is a syndrome heterogenous in its manifestation across patients. In the application of clinical theory and construct, investigators at this SMH- CRC has demonstrated reduction of heterogeneity relevant to brain structure and function as assessed with MRI, PET, post-mortem tissue, neuropsychological and cognitive performance, neurological signals, childhood development, oculomotor physiology, evoked potential, and etiologically relevant data on season of birth, pathology in biological relatives, and seropositivity for borna disease virus. The same approach to heterogeneity reduction results distinctive pharmacologic response profiles in course studies involving clinical trials methodology. Base don the importance of ethical issues on which schizophrenia research is now receiving intense scrutiny, this SMH-CRC has developed a new program of work on informed consent/ethics. Project support for the SMH-CRC investigators is obtained through competitive federal and foundation grants. Infra-structure support is provided through the following modules: Scientific Support, Assessment, Data Management, Clinical Biology and Subject Recruitment. A separately funded Training module is integral to the Center. The basic neuroscience faculty, also funded from other sources, greatly enriches the activities of the SMH-CRC.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Center Core Grants (P30)
Project #
5P30MH040279-13
Application #
2890333
Study Section
Clinical Centers and Special Projects Review Committee (CCSP)
Program Officer
Lebowitz, Barry D
Project Start
1986-02-15
Project End
2003-08-31
Budget Start
1999-09-01
Budget End
2000-08-31
Support Year
13
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Maryland Baltimore
Department
Psychiatry
Type
Schools of Medicine
DUNS #
003255213
City
Baltimore
State
MD
Country
United States
Zip Code
21201

  Publications

Warren, Kimberly R; Ball, M Patricia; Feldman, Stephanie et al. (2011) Exercise program adherence using a 5-kilometer (5K) event as an achievable goal in people with schizophrenia. Biol Res Nurs 13:383-90
Gao, Xue-Min; Elmer, Gregory I; Adams-Huet, Beverley et al. (2009) Social memory in mice: disruption with an NMDA antagonist and attenuation with antipsychotic drugs. Pharmacol Biochem Behav 92:236-42
Kelly, Deanna L; Wehring, Heidi J; Linthicum, Jared et al. (2009) Cardiac-related findings at autopsy in people with severe mental illness treated with clozapine or risperidone. Schizophr Res 107:134-8
Lahti, Adrienne C; Weiler, Martin A; Holcomb, Henry H et al. (2009) Modulation of limbic circuitry predicts treatment response to antipsychotic medication: a functional imaging study in schizophrenia. Neuropsychopharmacology 34:2675-90
Lahti, Adrienne C; Weiler, Martin A; Holcomb, Henry H et al. (2006) Correlations between rCBF and symptoms in two independent cohorts of drug-free patients with schizophrenia. Neuropsychopharmacology 31:221-30
Lahti, Adrienne C; Weiler, Martin A; Medoff, Deborah R et al. (2005) Functional effects of single dose first- and second-generation antipsychotic administration in subjects with schizophrenia. Psychiatry Res 139:19-30
McMahon, Robert P; Arndt, Stephan; Conley, Robert R (2005) More powerful two-sample tests for differences in repeated measures of adverse effects in psychiatric trials when only some patients may be at risk. Stat Med 24:11-21
Wilk, Christopher M; Gold, James M; Humber, Kathy et al. (2004) Brief cognitive assessment in schizophrenia: normative data for the Repeatable Battery for the Assessment of Neuropsychological Status. Schizophr Res 70:175-86
Lahti, Adrienne C; Holcomb, Henry H; Weiler, Martin A et al. (2004) Clozapine but not haloperidol Re-establishes normal task-activated rCBF patterns in schizophrenia within the anterior cingulate cortex. Neuropsychopharmacology 29:171-8
Lahti, Adrienne C; Holcomb, Henry H; Weiler, Martin A et al. (2003) Functional effects of antipsychotic drugs: comparing clozapine with haloperidol. Biol Psychiatry 53:601-8

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