The CRC is organized into a Scientific Administrative (Support) Core, four research support cores, and a training component. The Scientific Support Core co-ordinates activities among the 17 CRC investigators (including five funded neuroscience program faculty and 12 funded faculty in clinical research programs) and their 30 PHS and private research awards. During the current funding period, competitive research dollars have grown by 8 percent (page 126). The core provides the framework for the center?s business administration, scientific training, and review. A system is in place for continuing education and scientific review of CRC research. The core proposes to continue the center's Young Investigator Program (now called the Scientist Development Award), as well as the pilot project program. New to this core is ethics-related work, in collaboration with Paul Appelbaum, M.D., dealing with the capacity of schizophrenia patients to provide informed consent for participation in research. The functions of the core are performed by a Steering Committee, which is chaired by William Carpenter, M.D. The Steering Committee deals with budget, space, and resource allocations. Its subcommittees deal with subject assessment, data management, clinical biology, and subject recruitment. Continuing education and scientific review are carried out through mentoring, formal presentation of research protocols, formal educational sessions and journal clubs, review of manuscripts emanating from the CRC by the Center Director and the CRC biostatistician, monthly seminars with visiting scientists, and an annual neuroscience day.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Center Core Grants (P30)
Project #
5P30MH040279-16
Application #
6660539
Study Section
Project Start
2002-09-01
Project End
2003-08-31
Budget Start
Budget End
Support Year
16
Fiscal Year
2002
Total Cost
$266,631
Indirect Cost
Name
University of Maryland Baltimore
Department
Type
DUNS #
003255213
City
Baltimore
State
MD
Country
United States
Zip Code
21201
Warren, Kimberly R; Ball, M Patricia; Feldman, Stephanie et al. (2011) Exercise program adherence using a 5-kilometer (5K) event as an achievable goal in people with schizophrenia. Biol Res Nurs 13:383-90
Gao, Xue-Min; Elmer, Gregory I; Adams-Huet, Beverley et al. (2009) Social memory in mice: disruption with an NMDA antagonist and attenuation with antipsychotic drugs. Pharmacol Biochem Behav 92:236-42
Kelly, Deanna L; Wehring, Heidi J; Linthicum, Jared et al. (2009) Cardiac-related findings at autopsy in people with severe mental illness treated with clozapine or risperidone. Schizophr Res 107:134-8
Lahti, Adrienne C; Weiler, Martin A; Holcomb, Henry H et al. (2009) Modulation of limbic circuitry predicts treatment response to antipsychotic medication: a functional imaging study in schizophrenia. Neuropsychopharmacology 34:2675-90
Lahti, Adrienne C; Weiler, Martin A; Holcomb, Henry H et al. (2006) Correlations between rCBF and symptoms in two independent cohorts of drug-free patients with schizophrenia. Neuropsychopharmacology 31:221-30
Lahti, Adrienne C; Weiler, Martin A; Medoff, Deborah R et al. (2005) Functional effects of single dose first- and second-generation antipsychotic administration in subjects with schizophrenia. Psychiatry Res 139:19-30
McMahon, Robert P; Arndt, Stephan; Conley, Robert R (2005) More powerful two-sample tests for differences in repeated measures of adverse effects in psychiatric trials when only some patients may be at risk. Stat Med 24:11-21
Wilk, Christopher M; Gold, James M; Humber, Kathy et al. (2004) Brief cognitive assessment in schizophrenia: normative data for the Repeatable Battery for the Assessment of Neuropsychological Status. Schizophr Res 70:175-86
Lahti, Adrienne C; Holcomb, Henry H; Weiler, Martin A et al. (2004) Clozapine but not haloperidol Re-establishes normal task-activated rCBF patterns in schizophrenia within the anterior cingulate cortex. Neuropsychopharmacology 29:171-8
Lahti, Adrienne C; Holcomb, Henry H; Weiler, Martin A et al. (2003) Functional effects of antipsychotic drugs: comparing clozapine with haloperidol. Biol Psychiatry 53:601-8

Showing the most recent 10 out of 15 publications