Abstract

Overall Aims 1. To define the fundamental cognitive deficits in patients with schizophrenia, using principles adapted from cognitive and experimental neuropsychology. 2. To examine the neural circuit hypotheses of schizophrenia by investigating cognition in other conditions with known neural mechanisms that can serve as """"""""Model syndromes"""""""" such as Huntington's disease or patients with circumscribed lesions. 3. To study the relationships between disordered cognition and psychopathology using patients with mood disorders and/or with psychotic disorders. 4. To develop and apply new cognitive tasks to patients with schizophrenia, emphasizing tests found to be sensitive to brain areas considered abnormal (according to imaging and/or animal studies) in schizophrenia.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Center Core Grants (P30)
Project #
2P30MH043271-13
Application #
6204803
Study Section
Project Start
1999-09-30
Project End
2000-08-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
13
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Iowa
Department
Type
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

Rudd, Danielle S; Axelsen, Michael; Epping, Eric A et al. (2014) A genome-wide CNV analysis of schizophrenia reveals a potential role for a multiple-hit model. Am J Med Genet B Neuropsychiatr Genet 165B:619-26
Parker, Krystal L; Andreasen, Nancy C; Liu, Dawei et al. (2013) Eyeblink conditioning in unmedicated schizophrenia patients: a positron emission tomography study. Psychiatry Res 214:402-9
Onwuameze, O E; Nam, K W; Epping, E A et al. (2013) MAPK14 and CNR1 gene variant interactions: effects on brain volume deficits in schizophrenia patients with marijuana misuse. Psychol Med 43:619-31
Andreasen, Nancy C; Liu, Dawei; Ziebell, Steven et al. (2013) Relapse duration, treatment intensity, and brain tissue loss in schizophrenia: a prospective longitudinal MRI study. Am J Psychiatry 170:609-15
Andreasen, N C; Wilcox, M A; Ho, B-C et al. (2012) Statistical epistasis and progressive brain change in schizophrenia: an approach for examining the relationships between multiple genes. Mol Psychiatry 17:1093-102
Salinas, Joel; Mills, Elizabeth D; Conrad, Amy L et al. (2012) Sex differences in parietal lobe structure and development. Gend Med 9:44-55
Wassink, Thomas H; Epping, Eric A; Rudd, Danielle et al. (2012) Influence of ZNF804a on brain structure volumes and symptom severity in individuals with schizophrenia. Arch Gen Psychiatry 69:885-92
Andreasen, Nancy C; Nopoulos, Peg; Magnotta, Vincent et al. (2011) Progressive brain change in schizophrenia: a prospective longitudinal study of first-episode schizophrenia. Biol Psychiatry 70:672-9
Ho, Beng-Choon; Wassink, Thomas H; Ziebell, Steven et al. (2011) Cannabinoid receptor 1 gene polymorphisms and marijuana misuse interactions on white matter and cognitive deficits in schizophrenia. Schizophr Res 128:66-75
Pierson, Ronald; Johnson, Hans; Harris, Gregory et al. (2011) Fully automated analysis using BRAINS: AutoWorkup. Neuroimage 54:328-36

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