Abstract

Overall Aims: 1. To develop and maintain multiple inter-related phenomenological data bases of the major psychoses. 2. To describe short and intermediate term longitudinal course of new and recent onset psychotic disorders, and explore phenomenological and neurobiological predictors of psychosocial outcome. 3. To develop new approaches to assess the phenomenology of schizophrenia, with an emphasis on identifying and measuring abnormalities in basic cognize, processes that may lead to its heterogeneity of symptoms particularly cognitive dysmetria. 4. To continue our investigation of the role of developmental processes as causative or contributing factors to the occurrence of the illness. 5. To continue develop and revise assessment and diagnostic instruments and training methods as informed by results of psychometric studies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Center Core Grants (P30)
Project #
5P30MH043271-14
Application #
6344972
Study Section
Project Start
2000-09-01
Project End
2001-08-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
14
Fiscal Year
2000
Total Cost
$111,112
Indirect Cost

  Institution

Name
University of Iowa
Department
Type
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

Rudd, Danielle S; Axelsen, Michael; Epping, Eric A et al. (2014) A genome-wide CNV analysis of schizophrenia reveals a potential role for a multiple-hit model. Am J Med Genet B Neuropsychiatr Genet 165B:619-26
Parker, Krystal L; Andreasen, Nancy C; Liu, Dawei et al. (2013) Eyeblink conditioning in unmedicated schizophrenia patients: a positron emission tomography study. Psychiatry Res 214:402-9
Onwuameze, O E; Nam, K W; Epping, E A et al. (2013) MAPK14 and CNR1 gene variant interactions: effects on brain volume deficits in schizophrenia patients with marijuana misuse. Psychol Med 43:619-31
Andreasen, Nancy C; Liu, Dawei; Ziebell, Steven et al. (2013) Relapse duration, treatment intensity, and brain tissue loss in schizophrenia: a prospective longitudinal MRI study. Am J Psychiatry 170:609-15
Andreasen, N C; Wilcox, M A; Ho, B-C et al. (2012) Statistical epistasis and progressive brain change in schizophrenia: an approach for examining the relationships between multiple genes. Mol Psychiatry 17:1093-102
Salinas, Joel; Mills, Elizabeth D; Conrad, Amy L et al. (2012) Sex differences in parietal lobe structure and development. Gend Med 9:44-55
Wassink, Thomas H; Epping, Eric A; Rudd, Danielle et al. (2012) Influence of ZNF804a on brain structure volumes and symptom severity in individuals with schizophrenia. Arch Gen Psychiatry 69:885-92
Pierson, Ronald; Johnson, Hans; Harris, Gregory et al. (2011) Fully automated analysis using BRAINS: AutoWorkup. Neuroimage 54:328-36
Ho, Beng-Choon; Andreasen, Nancy C; Ziebell, Steven et al. (2011) Long-term antipsychotic treatment and brain volumes: a longitudinal study of first-episode schizophrenia. Arch Gen Psychiatry 68:128-37
Andreasen, Nancy C; Nopoulos, Peg; Magnotta, Vincent et al. (2011) Progressive brain change in schizophrenia: a prospective longitudinal study of first-episode schizophrenia. Biol Psychiatry 70:672-9

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