The Operational Core of this CRC is designed: 1) to survey the prevalence and correlates of depression, dementia and other late life mental disorders in the inpatient, long term care, out patient, and community- dwelling populations of the Center; 2) to recruit, assess, diagnose and track those populations; and 3) to serve as consultants to CRC investigators regarding recruitment, assessment, instrument validity and reliability, tracking and diagnosis of subjects. The Operational Core consist of two interacting components: the Assessment, Recruitment, and Tracking (ART) Service and Diagnostic Resources. The ART Services identifies potential research subjects for the CRC, is a resource for consultation on issues of assessment, maintains assessment standards and validity, and is resource for the Core's data acquisition that is conducted by research assistants without formal clinical training (directed by T. Harralson). Diagnostic Resources serves the CRC by providing expertise in psychiatric diagnoses (directed by J. Streim), neuropsychology (directed by R. Gur) and geriatric medicine (directed by J. Johnson). The Psychiatric Diagnosis subcomponent conducts standardized psychiatric assessments and neuropsychological evaluations to ensure that subjects entered into CRC research studies are well characterized. It also serves as consultative resource on clinical geriatric psychiatry and neuropsychology for CRC investigators, and works in conjunctions with the ART service to validate its methods. The Medical subcomponent works with the ART Service to establish and validate standardized methods for using medical records, clinician reports and subject (or proxy) report to characterize the medical status of research subjects both in terms of summary measurement of """"""""medical burden"""""""" and disease-specific measures. It also serves as a consultative resource on medical issues, and as a vehicle for obtaining individual medical assessments of CRC subjects.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Center Core Grants (P30)
Project #
3P30MH052129-07S2
Application #
6595030
Study Section
Project Start
2000-09-01
Project End
2002-08-31
Budget Start
Budget End
Support Year
7
Fiscal Year
2002
Total Cost
$262,244
Indirect Cost
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Gallo, Joseph J; Morales, Knashawn H; Bogner, Hillary R et al. (2013) Long term effect of depression care management on mortality in older adults: follow-up of cluster randomized clinical trial in primary care. BMJ 346:f2570
Wallace, Meredith L; Dombrovski, Alexandre Y; Morse, Jennifer Q et al. (2012) Coping with health stresses and remission from late-life depression in primary care: a two-year prospective study. Int J Geriatr Psychiatry 27:178-86
Joo, Jin Hui; Morales, Knashawn H; de Vries, Heather F et al. (2010) Disparity in use of psychotherapy offered in primary care between older african-american and white adults: results from a practice-based depression intervention trial. J Am Geriatr Soc 58:154-60
Wallace, Meredith L; Anderson, Stewart J; Mazumdar, Sati (2010) A stochastic multiple imputation algorithm for missing covariate data in tree-structured survival analysis. Stat Med 29:3004-16
Raue, Patrick J; Morales, Knashawn H; Post, Edward P et al. (2010) The wish to die and 5-year mortality in elderly primary care patients. Am J Geriatr Psychiatry 18:341-50
Gopalakrishnan, Raman; Ross, Jennifer; O'Brien, Charles et al. (2009) Course of late-life depression with alcoholism following combination therapy. J Stud Alcohol Drugs 70:237-41
Alexopoulos, George S; Reynolds 3rd, Charles F; Bruce, Martha L et al. (2009) Reducing suicidal ideation and depression in older primary care patients: 24-month outcomes of the PROSPECT study. Am J Psychiatry 166:882-90
Murphy, Susan A; Lynch, Kevin G; Oslin, David et al. (2007) Developing adaptive treatment strategies in substance abuse research. Drug Alcohol Depend 88 Suppl 2:S24-30
Gallo, Joseph J; Bogner, Hillary R; Morales, Knashawn H et al. (2007) The effect of a primary care practice-based depression intervention on mortality in older adults: a randomized trial. Ann Intern Med 146:689-98
Bogner, Hillary R; Bruce, Martha L; Reynolds 3rd, Charles F et al. (2007) The effects of memory, attention, and executive dysfunction on outcomes of depression in a primary care intervention trial: the PROSPECT study. Int J Geriatr Psychiatry 22:922-9

Showing the most recent 10 out of 45 publications