The original UCSF Center for AIDS Research (1988-1993) supported several activities in addition to the core facilities. The most important of these was the awarding of New Investigator Award. After the initial award, we redirected Planning and Evaluation funds to support state-of- the-art Workshops and Symposia. In the final year of the grant, with the limited remaining funds, CFAR funded a small Evolving Research Opportunity proposal. Two of the activities, support for new HIV investigators and support for evolving research opportunities in HIV research, form important components of the newly restricted CFAR. In retrospect, these activities proved to be very important factors in coordinating AIDS research through the CFAR mechanism and in encouraging productive collaborations at UCSF. The current CFAR application requests funds for New Investigator Awards, Pilot Project Awards and Evolving Research Opportunities. Budgetary restrictions preclude plans for Workshops and Symposia similar to those in the original CFAR. However, we have made preliminary plans for a seminar series that would bring basic research and clinical AIDS programs together. The goal of this seminar series is to generate new ideas, foster productive interactions and encourage collaborations between basic research investigators and clinicians across the Campus community. We plan to hold the seminars four times per year in the Gladstone Institute of Virology and Immunology AIDS Research Center Conference Room. Topics currently under consideration include Therapy and Quantification of Viral Load.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Center Core Grants (P30)
Project #
5P30MH059037-12
Application #
6111782
Study Section
Project Start
1999-03-01
Project End
2000-02-29
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
12
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Josefsson, Lina; von Stockenstrom, Susanne; Faria, Nuno R et al. (2013) The HIV-1 reservoir in eight patients on long-term suppressive antiretroviral therapy is stable with few genetic changes over time. Proc Natl Acad Sci U S A 110:E4987-96
Josefsson, Lina; Eriksson, Susanne; Sinclair, Elizabeth et al. (2012) Hematopoietic precursor cells isolated from patients on long-term suppressive HIV therapy did not contain HIV-1 DNA. J Infect Dis 206:28-34
Papasavvas, Emmanouil; Hsue, Priscilla; Reynolds, Griffin et al. (2012) Increased CD34+/KDR+ cells are not associated with carotid artery intima-media thickness progression in chronic HIV-positive subjects. Antivir Ther 17:557-63
Hunt, Peter W; Landay, Alan L; Sinclair, Elizabeth et al. (2011) A low T regulatory cell response may contribute to both viral control and generalized immune activation in HIV controllers. PLoS One 6:e15924
Hunt, Peter W; Hatano, Hiroyu; Sinclair, Elizabeth et al. (2011) HIV-specific CD4+ T cells may contribute to viral persistence in HIV controllers. Clin Infect Dis 52:681-7
Hunt, Peter W; Cao, Huyen L; Muzoora, Conrad et al. (2011) Impact of CD8+ T-cell activation on CD4+ T-cell recovery and mortality in HIV-infected Ugandans initiating antiretroviral therapy. AIDS 25:2123-31
Kitchen, Christina M R; Yeghiazarian, Lilit; Hoh, Rebecca et al. (2011) Immune activation, CD4+ T cell counts, and viremia exhibit oscillatory patterns over time in patients with highly resistant HIV infection. PLoS One 6:e21190
Favre, David; Stoddart, Cheryl A; Emu, Brinda et al. (2011) HIV disease progression correlates with the generation of dysfunctional naive CD8(low) T cells. Blood 117:2189-99
Hunt, Peter W; Martin, Jeffrey N; Sinclair, Elizabeth et al. (2011) Valganciclovir reduces T cell activation in HIV-infected individuals with incomplete CD4+ T cell recovery on antiretroviral therapy. J Infect Dis 203:1474-83
Favre, David; Mold, Jeff; Hunt, Peter W et al. (2010) Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease. Sci Transl Med 2:32ra36

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