This is an application for a Child Psychiatry Intervention Research Center (CPIRC) at New York State Psychiatric Institute. The CPIRC comprises: 1) The Central (Administrative) Core (Director: David Shaffer, M.D.) will perform administrative functions for all Cores, distribute small grants, oversee protocols to insure consumer-sensitive practice, insure coordination between the locally based NIMH Research Unit for Pediatric Psychopharmacology (RUPP), the Ruane Early-Diagnosis Center, and if funded the Anxiety Disorders IRC, will maintain a local Area Network (LAN) to serve all CPIRC users; 2) a Clinical Core (PI: Rachel Klein, Ph.D.) will recruit and screen subjects for treatment studies and will provide post-protocol care; 3) a Psycho-therapy Core (PI: Myrna Weissman, Ph.D.) will provide training and archival materials for manualized psychotherapies; 4) a Biostatistics, Measurement, Effectiveness Evaluation Core (PI: Andrew Leon, Ph.D.) will provide consultation on biostatistics, and research design, that will advise investigators on planning and conducting of effectiveness studies that will advise and train research staff on measurement choice and will manage and customize entry into a uniform database; and 5) a Psychopharmacology Core (PI: Laurence Greenhill, M.D.) that will monitor safety parameters, provide manuals to standardize psychopharmacology studies, will provide training and will facilitate pharmacological and basic science studies related to treatment response. Over the past four years, there has been a Child Psychiatry CRC that performed some but not all the treatment related functions that will be carried out by the CPIC that CRC screened over 1,698 individuals and referred over 718 to treatment protocols, provided consultation on 75 research projects, provided over 200 consultations related to publications and research-grant applications, and given courses whose combined audiences numbered in the hundreds. CRC users were productive: over a 4 year period wrote 367 publications that related to Center activities. This flourishing research environment, will be maintained by the CPIRC. The CPIRC will start life with a large number of experienced researchers and 28 funded treatment protocols. It will provide the infrastructure necessary for successful recruitment, sophisticated design badly needed in a field characterized by the widespread use of medical and psychotherapies of unproven value and safety for children and teens.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Center Core Grants (P30)
Project #
5P30MH060570-03
Application #
6392675
Study Section
Special Emphasis Panel (ZMH1-CRB-H (02))
Program Officer
Vitiello, Benedetto
Project Start
1999-09-24
Project End
2004-05-31
Budget Start
2001-06-01
Budget End
2002-05-31
Support Year
3
Fiscal Year
2001
Total Cost
$1,442,078
Indirect Cost
Name
New York State Psychiatric Institute
Department
Type
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
Whitaker, Agnes H; Feldman, Judith F; Lorenz, John M et al. (2011) Neonatal head ultrasound abnormalities in preterm infants and adolescent psychiatric disorders. Arch Gen Psychiatry 68:742-52
Loeb, Katharine L; Jones, Jennifer; Roberto, Christina A et al. (2011) Adolescent-adult discrepancies on the eating disorder examination: a function of developmental stage or severity of illness? Int J Eat Disord 44:567-72
Lipsitz, Joshua D; Gur, Merav; Albano, Anne Marie et al. (2011) A psychological intervention for pediatric chest pain: development and open trial. J Dev Behav Pediatr 32:153-7
Leon, Andrew C; Heo, Moonseong (2009) Sample Sizes Required to Detect Interactions between Two Binary Fixed-Effects in a Mixed-Effects Linear Regression Model. Comput Stat Data Anal 53:603-608
Leon, Andrew C; Davis, Lori L (2009) Enhancing clinical trial design of interventions for posttraumatic stress disorder. J Trauma Stress 22:603-11
Loeb, Katharine L; Walsh, B Timothy; Lock, James et al. (2007) Open trial of family-based treatment for full and partial anorexia nervosa in adolescence: evidence of successful dissemination. J Am Acad Child Adolesc Psychiatry 46:792-800
Young, Jami F; Mufson, Laura; Davies, Mark (2006) Impact of comorbid anxiety in an effectiveness study of interpersonal psychotherapy for depressed adolescents. J Am Acad Child Adolesc Psychiatry 45:904-12
Mufson, Laura; Dorta, Kristen Pollack; Wickramaratne, Priya et al. (2004) A randomized effectiveness trial of interpersonal psychotherapy for depressed adolescents. Arch Gen Psychiatry 61:577-84
Mufson, Laura; Gallagher, Trish; Dorta, Kristen Pollack et al. (2004) A group adaptation of Interpersonal Psychotherapy for depressed adolescents. Am J Psychother 58:220-37
Kotler, Lisa A; Devlin, Michael J; Davies, Mark et al. (2003) An open trial of fluoxetine for adolescents with bulimia nervosa. J Child Adolesc Psychopharmacol 13:329-35

Showing the most recent 10 out of 11 publications