The Scripps Preclinical NeuroAIDS Studies (SNAPS) group has organized an application for a Core support Program for Mental Health/AIDS Research (CSPAR) Center in order to foster a multi- disciplinary, synergistic approach to the mental health consequence of HIV infection. Through the combined insights of scientists performing virologic, immunologic , pathologic, neurobiologic, chemical, molecular and cellular biologic investigations we can maximize the effort and resulting progress made towards understanding, treatment, and funds for relevant studies, examine Viral Pathogenesis, the Host Response, Pathogenesis of Host Defenses, Downstream Effects on Neural Systems and Therapy, with the goal of understanding the consequences of HIV on the nervous system. This would include identifying the cellular and molecular mechanisms underlying the effects of HIV on the brain, and the potential for developing and testing potential therapeutics to prevent or treat CNS disease. To support this research, five research Cores: Behavioral Assessment Core Physiology Core, Immunological Assay Core, Functional Genomics Core, and Protein Chemistry Core have been organized. Direction and leadership will be provided y an Administrative Core. A Developmental Core will also be an integral part of the Center to help expand the neuroAIDS research effort. The strength of this Center lies in the productivity and creativity of the participating faculty and the unique collaborative environment in place at TSRI. The SNAPS will also provide a resource for neuroAIDS research, allowing the application of the preclinical work performed by SNAPS scientists to translational work in the clinic. This program was conceived as a means of fostering inter- disciplinary approaches to the study of neuroAIDS, and with recent advances in the scientific fields encompassed by these investigations, the opportunities for the fusion of research in these areas has never been more promising. The value added by the addition of Core support proposed in this application will be to extend and facilitate those existing studies, while fostering new collaboration and exploration that are not possible at the present time.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Center Core Grants (P30)
Project #
5P30MH062261-05
Application #
6805085
Study Section
Special Emphasis Panel (ZMH1-BRB-T (04))
Program Officer
Rausch, Dianne M
Project Start
2000-09-30
Project End
2006-02-28
Budget Start
2004-09-01
Budget End
2006-02-28
Support Year
5
Fiscal Year
2004
Total Cost
$2,088,660
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
781613492
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Sathyanesan, Monica; Watt, Michael J; Haiar, Jacob M et al. (2018) Carbamoylated erythropoietin modulates cognitive outcomes of social defeat and differentially regulates gene expression in the dorsal and ventral hippocampus. Transl Psychiatry 8:113
Zhou, Tian; Su, Hang; Dash, Prasanta et al. (2018) Creation of a nanoformulated cabotegravir prodrug with improved antiretroviral profiles. Biomaterials 151:53-65
Thangaraj, Annadurai; Periyasamy, Palsamy; Liao, Ke et al. (2018) HIV-1 TAT-mediated microglial activation: role of mitochondrial dysfunction and defective mitophagy. Autophagy 14:1596-1619
Kevadiya, Bhavesh D; Ottemann, Brendan M; Thomas, Midhun Ben et al. (2018) Neurotheranostics as personalized medicines. Adv Drug Deliv Rev :
Wiesman, Alex I; O'Neill, Jennifer; Mills, Mackenzie S et al. (2018) Aberrant occipital dynamics differentiate HIV-infected patients with and without cognitive impairment. Brain 141:1678-1690
Periyasamy, Palsamy; Thangaraj, Annadurai; Guo, Ming-Lei et al. (2018) Epigenetic Promoter DNA Methylation of miR-124 Promotes HIV-1 Tat-Mediated Microglial Activation via MECP2-STAT3 Axis. J Neurosci 38:5367-5383
Zhou, Tian; Lin, Zhiyi; Puligujja, Pavan et al. (2018) Optimizing the preparation and stability of decorated antiretroviral drug nanocrystals. Nanomedicine (Lond) 13:871-885
Yang, Lu; Niu, Fang; Yao, Honghong et al. (2018) Exosomal miR-9 Released from HIV Tat Stimulated Astrocytes Mediates Microglial Migration. J Neuroimmune Pharmacol 13:330-344
Lin, Zhiyi; Gautam, Nagsen; Alnouti, Yazen et al. (2018) ProTide generated long-acting abacavir nanoformulations. Chem Commun (Camb) 54:8371-8374
McMillan, JoEllyn; Szlachetka, Adam; Zhou, Tian et al. (2018) Pharmacokinetic testing of a first generation cabotegravir prodrug in rhesus macaques. AIDS :

Showing the most recent 10 out of 374 publications