Abstract

-BIOINFORMATICS CORE The Bioinformatics Core analyzes high-throughput sequencing (HTS) datasets for NINDS-funded and other NINDS-priority investigators at UNC. The Bioinformatics Core leverages Center grant support from NINDS, an Intellectual Disabilities Research Center (IDDRC) grant from NICHD (awarded to the Carolina Institute for Developmental Disabilities; CIDD), and Institutional support from the Lineberger Comprehensive Cancer Center (LCCC). This core serves NINDS-funded and priority faculty, CIDD faculty who study neurodevelopmental disorders, and LCCC faculty who study brain cancers. Support for the Core Director is split 50:50 between NINDS/CIDD and LCCC, while two additional bioinformaticians (TBN) will be supported, one by NINDS/CIDD (50:50) and the other by LCCC (100%).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
5P30NS045892-18
Application #
10063967
Study Section
Special Emphasis Panel (ZNS1)
Project Start
2003-07-01
Project End
2021-11-30
Budget Start
2020-12-01
Budget End
2021-11-30
Support Year
18
Fiscal Year
2021
Total Cost
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Song, Liujiang; Llanga, Telmo; Conatser, Laura M et al. (2018) Serotype survey of AAV gene delivery via subconjunctival injection in mice. Gene Ther 25:402-414
Zhang, Jing; Wu, Tao; Simon, Jeremy et al. (2018) VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma. Science 361:290-295
Boyer, Nicholas P; Monkiewicz, Caroline; Menon, Shalini et al. (2018) Mammalian TRIM67 Functions in Brain Development and Behavior. eNeuro 5:
Sidorov, Michael S; Judson, Matthew C; Kim, Hyojin et al. (2018) Enhanced Operant Extinction and Prefrontal Excitability in a Mouse Model of Angelman Syndrome. J Neurosci 38:2671-2682
Crowther, Andrew J; Lim, Szu-Aun; Asrican, Brent et al. (2018) An Adeno-Associated Virus-Based Toolkit for Preferential Targeting and Manipulating Quiescent Neural Stem Cells in the Adult Hippocampus. Stem Cell Reports 10:1146-1159
Allard, Denise E; Wang, Yan; Li, Jian Joel et al. (2018) Schwann cell-derived periostin promotes autoimmune peripheral polyneuropathy via macrophage recruitment. J Clin Invest 128:4727-4741
Yeh, Chia-Yu; Asrican, Brent; Moss, Jonathan et al. (2018) Mossy Cells Control Adult Neural Stem Cell Quiescence and Maintenance through a Dynamic Balance between Direct and Indirect Pathways. Neuron 99:493-510.e4
Thaxton, Courtney; Kloth, Alexander D; Clark, Ellen P et al. (2018) Common Pathophysiology in Multiple Mouse Models of Pitt-Hopkins Syndrome. J Neurosci 38:918-936
Nakagawa, Naoki; Li, Jingjun; Yabuno-Nakagawa, Keiko et al. (2017) APC sets the Wnt tone necessary for cerebral cortical progenitor development. Genes Dev 31:1679-1692
Hirsch, Matthew L; Conatser, Laura M; Smith, Sara M et al. (2017) AAV vector-meditated expression of HLA-G reduces injury-induced corneal vascularization, immune cell infiltration, and fibrosis. Sci Rep 7:17840

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