Facilitated access to high quality, clinically annotated biospecimens is critical for leveraging new genomic and proteomic technologies to better understand diseases of the human nervous system. On-going efforts at our institution have created several biospecimen repositories for select nervous system disorders such as Alzheimer's disease, but human specimen resources are less adequate for many other disease types. Accordingly, the goal of the Biospecimen and Clinical Data Acquisition Core is to facilitate the coordinated collection, processing, storage, and distribution of biospecimens and clinical data from patients within a broad representation of disorders of the nervous system.
The first aim of this core is to initiate the collection of biospecimens and associated clinical data from patient populations where little support currently exists. The Core will assist investigators who wish to collect biospecimens for specific research protocols, but will also act as a more general resource to bank biospecimens from patients with disorders of the nervous system for future retrospective studies. Collected specimens will include serum, plasma, CSF, genomic DNA, and in some cases, tissue (e.g. surgically resected epileptic foci). Where appropriate, such as in diseases as multiple sclerosis, emphasis will be placed on collecting samples at multiple time points to create a set of biospecimens that can be analyzed over the patient's clinical course.
The second aim of this core is to catalyze the integration of several large, pre-existing biorepositories and clinical databases using a set of common data elements and a web-based biospecimen informatics system (""""""""nsTissue Core"""""""") to create a virtual repository of biospecimens from patients with a wide variety of neurological and psychaitric diseases. As part of this aim, we will also seek to harmonize collection and processing protocols and to share technical resources, making the collection of biospecimens from patients with disorders of the nervous system at our institution more efficient and uniform. As a model for this approach, we will seek to integrate resources from our Alzheimer's Disease Research Center (ADRC) and the Movement Disorders Clinic.
The third aim of this core is to make accessible an inventory of available biospecimen resources and deidentified data generated from the first two aims. Authorized intramural and extramural neuroscience investigators will be able to query this resource, for the purposes of sharing collected biospecimens to promote novel translational studies and collaborations in translational neuroscience.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
5P30NS057105-05
Application #
8119528
Study Section
Special Emphasis Panel (ZNS1)
Project Start
Project End
2013-08-31
Budget Start
2010-09-01
Budget End
2011-08-31
Support Year
5
Fiscal Year
2010
Total Cost
$227,455
Indirect Cost
Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Al-Hasani, Ream; Wong, Jenny-Marie T; Mabrouk, Omar S et al. (2018) In vivo detection of optically-evoked opioid peptide release. Elife 7:
Yan, Ying; Hunter, Daniel A; Schellhardt, Lauren et al. (2018) Nerve stepping stone has minimal impact in aiding regeneration across long acellular nerve allografts. Muscle Nerve 57:260-267
DeVos, Sarah L; Miller, Rebecca L; Schoch, Kathleen M et al. (2017) Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy. Sci Transl Med 9:
Ransdell, Joseph L; Dranoff, Edward; Lau, Brandon et al. (2017) Loss of Nav?4-Mediated Regulation of Sodium Currents in Adult Purkinje Neurons Disrupts Firing and Impairs Motor Coordination and Balance. Cell Rep 19:532-544
Ee, Xueping; Yan, Ying; Hunter, Daniel A et al. (2017) Transgenic SCs expressing GDNF-IRES-DsRed impair nerve regeneration within acellular nerve allografts. Biotechnol Bioeng 114:2121-2130
Gangolli, Mihika; Holleran, Laurena; Hee Kim, Joong et al. (2017) Quantitative validation of a nonlinear histology-MRI coregistration method using generalized Q-sampling imaging in complex human cortical white matter. Neuroimage 153:152-167
Wong, Terence T W; Zhang, Ruiying; Zhang, Chi et al. (2017) Label-free automated three-dimensional imaging of whole organs by microtomy-assisted photoacoustic microscopy. Nat Commun 8:1386
Jong, Yuh-Jiin I; O'Malley, Karen L (2017) Mechanisms Associated with Activation of Intracellular Metabotropic Glutamate Receptor, mGluR5. Neurochem Res 42:166-172
McCall, Jordan G; Siuda, Edward R; Bhatti, Dionnet L et al. (2017) Locus coeruleus to basolateral amygdala noradrenergic projections promote anxiety-like behavior. Elife 6:
Seugnet, Laurent; Dissel, Stephane; Thimgan, Matthew et al. (2017) Identification of Genes that Maintain Behavioral and Structural Plasticity during Sleep Loss. Front Neural Circuits 11:79

Showing the most recent 10 out of 380 publications