Abstract

In this Institutional Center Core Grant to Support Neuroscience Research, we propose to continue to develop an innovative Imaging Center that serves NINDS-funded Harvard Medical School (HMS) and Boston Children's Hospital (BCH) investigators. This state-of-the-art core facility provides important resources to the HMS and BCH neuroscience community, and will perform essential services that are difficult and impractical for individual laboratories to provide on their own. The experimental opportunities and innovative services provided by the Imaging Center will give area neuroscientists access to unique equipment and training in several new cutting-edge methodologies, greatly benefiting the research programs of NINDS-funded investigators at these institutions. Moreover, the Center will function as the centerpiece of a concerted effort to strengthen ties between the neuroscience communities at HMS and BCH. Through the continued development of this Center, we hope to shift from a complete reliance on individual laboratory-centered research to a more cost-effective and productive use of extraordinary cores while further deepening existing ties between these two vibrant neuroscience communities.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
5P30NS072030-07
Application #
9568032
Study Section
Special Emphasis Panel (ZNS1)
Project Start
Project End
Budget Start
2018-09-01
Budget End
2019-08-31
Support Year
7
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
Harvard Medical School
Department
Type
DUNS #
047006379
City
Boston
State
MA
Country
United States
Zip Code

  Publications

Chantre, Christophe O; Campbell, Patrick H; Golecki, Holly M et al. (2018) Production-scale fibronectin nanofibers promote wound closure and tissue repair in a dermal mouse model. Biomaterials 166:96-108
Jeanne, James M; Fi?ek, Mehmet; Wilson, Rachel I (2018) The Organization of Projections from Olfactory Glomeruli onto Higher-Order Neurons. Neuron 98:1198-1213.e6
Jackman, Skyler L; Chen, Christopher H; Chettih, Selmaan N et al. (2018) Silk Fibroin Films Facilitate Single-Step Targeted Expression of Optogenetic Proteins. Cell Rep 22:3351-3361
Yung, Andrea R; Druckenbrod, Noah R; Cloutier, Jean-François et al. (2018) Netrin-1 Confines Rhombic Lip-Derived Neurons to the CNS. Cell Rep 22:1666-1680
Turecek, Josef; Regehr, Wade G (2018) Synaptotagmin 7 Mediates Both Facilitation and Asynchronous Release at Granule Cell Synapses. J Neurosci 38:3240-3251
Syed, Ismail; Lee, Jennifer; Moraes-Vieira, Pedro M et al. (2018) Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis. Cell Metab 27:419-427.e4
Cheadle, Lucas; Tzeng, Christopher P; Kalish, Brian T et al. (2018) Visual Experience-Dependent Expression of Fn14 Is Required for Retinogeniculate Refinement. Neuron 99:525-539.e10
Hrvatin, Sinisa; Hochbaum, Daniel R; Nagy, M Aurel et al. (2018) Single-cell analysis of experience-dependent transcriptomic states in the mouse visual cortex. Nat Neurosci 21:120-129
Renthal, William; Boxer, Lisa D; Hrvatin, Sinisa et al. (2018) Characterization of human mosaic Rett syndrome brain tissue by single-nucleus RNA sequencing. Nat Neurosci 21:1670-1679
Sieker, Jakob T; Proffen, Benedikt L; Waller, Kimberly A et al. (2018) Transcriptional profiling of synovium in a porcine model of early post-traumatic osteoarthritis. J Orthop Res :

Showing the most recent 10 out of 68 publications