Abstract

IMAGE AND SPECTROSCOPY ANALYSIS AND VISUALIZATION CORE PI: Christophe Lenglet, PhD; co-PI: Noam Harel, PhD This Core will provide advanced analysis tools and resources for a variety of neuroimaging modalities including structural MRI, High Angular Resolution Diffusion Imaging (HARDI), Diffusion Spectroscopic Imaging (DSI), functional MRI (fMRI), intrinsic relaxation parameter imaging, MR spectroscopy (MRS), as well as Positron Emission Tomography (PET) and Computed Tomography (CT). The unique needs of each of these modalities will be served through shared computing equipment, software and expert personnel in the Core. Additionally, the Core will provide support for multi-modality image analysis. Image reconstruction, analysis and visualization require sophisticated mathematical modeling and computational resources. The overall goal of this Core is to provide such unique resources for human and animal neuroimaging research. They will enable individuals to generate high-quality images from high (3 and 4T) and ultrahigh (7T and higher) field MR scanners and to efficiently analyze them through state-of-the-art methods.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
5P30NS076408-04
Application #
8915762
Study Section
Special Emphasis Panel (ZNS1-SRB-R)
Project Start
Project End
2016-06-30
Budget Start
2015-07-01
Budget End
2016-06-30
Support Year
4
Fiscal Year
2015
Total Cost
$101,737
Indirect Cost
$34,805

  Institution

Name
University of Minnesota Twin Cities
Department
Type
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Deelchand, Dinesh K; Kantarci, Kejal; Öz, Gülin (2018) Improved localization, spectral quality, and repeatability with advanced MRS methodology in the clinical setting. Magn Reson Med 79:1241-1250
Slopsema, Julia P; Peña, Edgar; Patriat, Remi et al. (2018) Clinical deep brain stimulation strategies for orientation-selective pathway activation. J Neural Eng 15:056029
Joers, James M; Deelchand, Dinesh K; Lyu, Tianmeng et al. (2018) Neurochemical abnormalities in premanifest and early spinocerebellar ataxias. Ann Neurol 83:816-829
Deelchand, Dinesh K; Auerbach, Edward J; Kobayashi, Naoharu et al. (2018) Transverse relaxation time constants of the five major metabolites in human brain measured in vivo using LASER and PRESS at 3 T. Magn Reson Med 79:1260-1265
Pisharady, Pramod Kumar; Sotiropoulos, Stamatios N; Duarte-Carvajalino, Julio M et al. (2018) Estimation of white matter fiber parameters from compressed multiresolution diffusion MRI using sparse Bayesian learning. Neuroimage 167:488-503
Olman, Cheryl A; Bao, Pinglei; Engel, Stephen A et al. (2018) Hemifield columns co-opt ocular dominance column structure in human achiasma. Neuroimage 164:59-66
Friedrich, Jillian; Kordasiewicz, Holly B; O'Callaghan, Brennon et al. (2018) Antisense oligonucleotide-mediated ataxin-1 reduction prolongs survival in SCA1 mice and reveals disease-associated transcriptome profiles. JCI Insight 3:
Chu, Shu-Hsien; Parhi, Keshab K; Lenglet, Christophe (2018) Function-specific and Enhanced Brain Structural Connectivity Mapping via Joint Modeling of Diffusion and Functional MRI. Sci Rep 8:4741
Adanyeguh, Isaac M; Monin, Marie-Lorraine; Rinaldi, Daisy et al. (2018) Expanded neurochemical profile in the early stage of Huntington disease using proton magnetic resonance spectroscopy. NMR Biomed 31:
Wilson, Sylia; Malone, Stephen M; Hunt, Ruskin H et al. (2018) Problematic alcohol use and hippocampal volume in a female sample: disentangling cause from consequence using a co-twin control study design. Psychol Med 48:1673-1684

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