Research Animal Diagnostic Laboratory

Fox, James G.

Abstract

This proposal will provide the faculty of the Massachusetts Institute of Technology a resource to support their efforts in the utilization of laboratory animals for research and teaching. Over 100 principal investigators use approximately 100,000 animals annually at the Institute. We also provide diagnostic services for 19 Boston area biomedical facilities with an accumulative daily census of 75,000 animals. The Research Animal Diagnostic Laboratory is adequately staffed and equipped to provide diagnostic services in hematology, microbiology, parasitology, clinical chemistry, virology, histology and gross and microscopic pathology to support the animal disease control program of the Institute. In addition, the diagnostic laboratory will support research activities in the study of diseases of laboratory animals and will continue to assist in the recognition and development of animal analogs to human disease. The study of the epidemiology of campylobacteriosis will also be pursued. Further, the laboratory staff will continue in and facilitate expansion of the present teaching programs of the Division of Comparative Medicine, for graduate, undergraduate and summer veterinary students. It is essential to the overall research program that diagnostic laboratories and veterinary support be available at the Institute.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Center for Research Resources (NCRR)
• Type: Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Material Resource Grants (P40)
• Project #: 2P40RR001046-10
• Application #: 3103356
• Study Section: Animal Resources Advisory Committee (AR)
• Project Start: 1976-05-01
• Project End: 1990-04-30
• Budget Start: 1985-05-01
• Budget End: 1986-04-30
• Support Year: 10
• Fiscal Year: 1985

Institution

• Name: Massachusetts Institute of Technology
• Type: Graduate Schools
• City: Cambridge
• State: MA
• Country: United States

Publications

Dykstra, M J; Astrofsky, K M; Schrenzel, M D et al. (2001) High mortality in a large-scale zebrafish colony (Brachydanio rerio Hamilton & Buchanan, 1822) associated with Lecythophora mutabilis (van Beyma) W. Gams & McGinnis. Comp Med 51:361-8

Shen, Z; Feng, Y; Dewhirst, F E et al. (2001) Coinfection of enteric Helicobacter spp. and Campylobacter spp. in cats. J Clin Microbiol 39:2166-72

Kwiecien, J M; Blanco, M; Fox, J G et al. (2000) Neuropathology of bouncer Long Evans, a novel dysmyelinated rat. Comp Med 50:503-10

Fox, J G; Chien, C C; Dewhirst, F E et al. (2000) Helicobacter canadensis sp. nov. isolated from humans with diarrhea as an example of an emerging pathogen. J Clin Microbiol 38:2546-9

Jackson, L R; Trudel, L J; Fox, J G et al. (1999) Monoclonal antibody production in murine ascites. II. Production characteristics. Lab Anim Sci 49:81-6

Jackson, L R; Trudel, L J; Fox, J G et al. (1999) Monoclonal antibody production in murine ascites. I. Clinical and pathologic features. Lab Anim Sci 49:70-80

McCathey, S N; Shomer, N H; Schrenzel, M D et al. (1999) Colonization and tissue tropism of Helicobacter pylori and a novel urease-negative Helicobacter species in ICR mice are independent of route of exposure. Helicobacter 4:249-59

Shomer, N H; Dangler, C A; Marini, R P et al. (1998) Helicobacter bilis/Helicobacter rodentium co-infection associated with diarrhea in a colony of scid mice. Lab Anim Sci 48:455-9

Shen, Z; Fox, J G; Dewhirst, F E et al. (1997) Helicobacter rodentium sp. nov., a urease-negative Helicobacter species isolated from laboratory mice. Int J Syst Bacteriol 47:627-34

Fox, J G; Dangler, C A; Sager, W et al. (1997) Helicobacter mustelae-associated gastric adenocarcinoma in ferrets (Mustela putorius furo). Vet Pathol 34:225-9