The mission of the Mouse Mutant Resource (MMR) at TJL is to provide a continuing source of new spontaneous mutations for biomedical and biological research. Spontaneous mutations in the mouse are a major source of models for human disorders and have the advantage over genetically engineered mutations in that they are first recognized by producing relevant phenotypes and do not require prior knowledge of the underlying genes. The specific objectives of the MMR program are to: (1) discover new spontaneous mutations in the mouse; (2) characterize the new mutants genetically, phenotypically, and pathologically; (3) establish the new mutations in strains suitable for further analysis; (4) preserve the mutations as frozen embryos or gametes to assure their continued availability and as DNA for future molecular analysis; (5) provide mutant mice and controls to other investigators; and (6) provide information about the mutant mice to others. The new mutations are discovered from among phenotypic deviants appearing in TJL large breeding colonies. They are characterized genetically by determining the mode of inheritance, testing for allelism with known mutations that produce a similar phenotype, and determining the chromosomal location. Each new mutant is characterized phenotypically by observing its growth, viability, fertility, life span, and behavior, and by defining its anatomical, histopathological, and physiological abnormalities. For selected mutants whose phenotype resembles that of an important human disease, the investigators will do further genetic and molecular analysis to identify the mutant gene. The investigators do more in depth analysis on mutants with phenotypes for which a member of the group or a collaborator has specific expertise. The MMR team has expertise in hearing, vision, bone biology, reproduction, and neuropathology. All new mutants with potential for biomedical research will be maintained, preserved as frozen embryos and DNA, and described in the open literature and/or on the MMR and TJL Websites. The overall purpose of the MMR is to make new mutant models available to other investigators for biomedical research.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Material Resource Grants (P40)
Project #
2P40RR001183-26
Application #
6684200
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Program Officer
Grieder, Franziska B
Project Start
1978-07-01
Project End
2008-04-30
Budget Start
2003-07-21
Budget End
2004-04-30
Support Year
26
Fiscal Year
2003
Total Cost
$1,490,411
Indirect Cost
Name
Jackson Laboratory
Department
Type
DUNS #
042140483
City
Bar Harbor
State
ME
Country
United States
Zip Code
04609
Davisson, Muriel T; Cook, Susan A; Akeson, Ellen C et al. (2015) Kidney adysplasia and variable hydronephrosis, a new mutation affecting the odd-skipped related 1 gene in the mouse, causes variable defects in kidney development and hydronephrosis. Am J Physiol Renal Physiol 308:F1335-42
Sakami, Sanae; Kolesnikov, Alexander V; Kefalov, Vladimir J et al. (2014) P23H opsin knock-in mice reveal a novel step in retinal rod disc morphogenesis. Hum Mol Genet 23:1723-41
Li, Qiaoli; Pratt, C Herbert; Dionne, Louise A et al. (2014) Spontaneous asj-2J mutant mouse as a model for generalized arterial calcification of infancy: a large deletion/insertion mutation in the Enpp1 gene. PLoS One 9:e113542
Korstanje, Ron; Caputo, Christina R; Doty, Rosalinda A et al. (2014) A mouse Col4a4 mutation causing Alport glomerulosclerosis with abnormal collagen ?3?4?5(IV) trimers. Kidney Int 85:1461-8
Potter, Gregory B; Santos, Marta; Davisson, Muriel T et al. (2013) Missense mutation in mouse GALC mimics human gene defect and offers new insights into Krabbe disease. Hum Mol Genet 22:3397-414
Nilsson, Ida A K; Lindfors, Charlotte; Schalling, Martin et al. (2013) Anorexia and hypothalamic degeneration. Vitam Horm 92:27-60
Schramm, R Dee; Li, Shuai; Harris, Belinda S et al. (2012) A novel mouse Dscam mutation inhibits localization and shedding of DSCAM. PLoS One 7:e52652
Davisson, Muriel T; Bergstrom, David E; Reinholdt, Laura G et al. (2012) Discovery Genetics - The History and Future of Spontaneous Mutation Research. Curr Protoc Mouse Biol 2:103-118
Fairfield, Heather; Gilbert, Griffith J; Barter, Mary et al. (2011) Mutation discovery in mice by whole exome sequencing. Genome Biol 12:R86
Davisson, Muriel T; Bronson, Roderick T; Tadenev, Abigail L D et al. (2011) A spontaneous mutation in contactin 1 in the mouse. PLoS One 6:e29538

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