Funds are requested to establish a diagnostic laboratory for research animals in the School of Medicine of the University of Pennsylvania. The laboratory will be a core element in the animal care program of the School of Medicine. Additionally, it will provide diagnostic services to other departments of the University and to biomedical institutions in Philadelphia. Diagnostic procedures performed by the laboratory will include necropsy, microscopic examination of animal tissues, isolation and identification of specific pathogens and other appropriate laboratory procedures. Emphasis will be placed on permanent documentation of laboratory findings for the benefit of investigators, professional and other graduate students. Specific programs which will be developed with the aid of the laboratory are: vendor surveillance; conditioning protocols; surveillance of resident animals; environmental surveillance; research assistance to investigators; diagnostic services and consultations to biomedical institutions; and in-depth investigations of unique conditions of laboratory animals. Long term objectives include provision of professional, scientific and academic services to investigators and students as an integral part of the multimillion dollar research activities which involve laboratory animals in the School of Medicine and in proximal institutions.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Material Resource Grants (P40)
Project #
5P40RR001555-02
Application #
3103458
Study Section
Animal Resources Advisory Committee (AR)
Project Start
1984-09-01
Project End
1986-08-31
Budget Start
1985-09-01
Budget End
1986-08-31
Support Year
2
Fiscal Year
1985
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Urs, Sumithra; Henderson, Terry; Le, Phuong et al. (2012) Tissue-specific expression of Sprouty1 in mice protects against high-fat diet-induced fat accumulation, bone loss and metabolic dysfunction. Br J Nutr 108:1025-33
Le, Phuong; Kawai, Masanobu; Bornstein, Sheila et al. (2012) A high-fat diet induces bone loss in mice lacking the Alox5 gene. Endocrinology 153:6-16
Tang, Yuefeng; Harrington, Anne; Yang, Xuehui et al. (2010) The contribution of the Tie2+ lineage to primitive and definitive hematopoietic cells. Genesis 48:563-7
Urs, Sumithra; Venkatesh, Deepak; Tang, Yuefeng et al. (2010) Sprouty1 is a critical regulatory switch of mesenchymal stem cell lineage allocation. FASEB J 24:3264-73
Chen, Pei-Yu; Friesel, Robert (2009) FGFR1 forms an FRS2-dependent complex with mTOR to regulate smooth muscle marker gene expression. Biochem Biophys Res Commun 382:424-9
Chen, Pei-Yu; Simons, Michael; Friesel, Robert (2009) FRS2 via fibroblast growth factor receptor 1 is required for platelet-derived growth factor receptor beta-mediated regulation of vascular smooth muscle marker gene expression. J Biol Chem 284:15980-92
Cai, Shuang; Xie, Yumei; Bagby, Taryn R et al. (2008) Intralymphatic chemotherapy using a hyaluronan-cisplatin conjugate. J Surg Res 147:247-52
Venkatesh, Deepak A; Park, Kyung-Sook; Harrington, Anne et al. (2008) Cardiovascular and hematopoietic defects associated with Notch1 activation in embryonic Tie2-expressing populations. Circ Res 103:423-31
Tang, Yuefeng; Urs, Sumithra; Liaw, Lucy (2008) Hairy-related transcription factors inhibit Notch-induced smooth muscle alpha-actin expression by interfering with Notch intracellular domain/CBF-1 complex interaction with the CBF-1-binding site. Circ Res 102:661-8
Urs, Sumithra; Roudabush, Alice; O'Neill, Christine F et al. (2008) Soluble forms of the Notch ligands Delta1 and Jagged1 promote in vivo tumorigenicity in NIH3T3 fibroblasts with distinct phenotypes. Am J Pathol 173:865-78

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