This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Inherited immunodeficiency disorders are an important class of genetic disease. Dr. Peter Felsburg has instituted a full-service clinical immunology laboratory for dogs and cats at the Veterinary School, University of Pennsylvania, which will aid the screening laboratory in identifying companion animals with primary immunodeficiency diseases. The testing provided by the laboratory includes flow cytometry to determine in dogs: CD3, CD4, CD8, CD14, CD21, CD45RA, TCRa , and TCRgd; in cats: CD5, CD4, CD8, CD14, and CD21. In addition, a panel to detect defective leukocyte integrin expression includes CD11a, CD11b, CD11c, and CD18. We also now offer serum immunoglobulin quantitation (IgG, IgM, and IgA), a lymphocyte proliferation assay, and a neutrophil/monocyte function test that measures hydrogen peroxide production. With this battery of tests, we will be better able to identify genetic abnormalities in immune function, expanding the capacity to uncover homologes of human genetic disease.
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