This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. DESCRIPTION (provided by applicant): The critical shortage of rhesus monkeys has created an urgent need to develop alternative nonhuman primate models for biomedical research. The vervet / African green monkey (Chlorocebus aethiops) is an ideal candidate to fill this position. Vervets are Old World monkeys that resemble the rhesus in behavior, physiology and anatomy. Caribbean-derived vervets are readily available and are less expensive than rhesus, and because they do not carry Herpesvirus simiae (B virus), they present fewer health and safety risks than rhesus or other Asian macaque alternatives. The UCLA Vervet Research Colony (VRC) is an established center that has supported local research in vervet monkey neurobiology, behavior and genetics for 29 years, making it uniquely positioned to serve as the basis for a national resource center for vervet monkeys. The extensive genetic and behavioral database collected on vervets at the VRC make this a particularly valuable resource for collaborative research in a number of areas of biomedical interest, including obesity, diabetes, aging, psychiatric and behavioral disorders, and vulnerability for cardiovascular disease. Support from an NCRR P40 grant will enable the VRC to a) increase the supply of nonhuman primates for biomedical research by breeding US colony-born, specific pathogen free (SPF) vervets of known age and medical history for NIH-funded investigators; b) provide vervets with specific characteristics and conditions (e.g., aged, impulsive, obese, diabetic) to outside investigators; c) maintain a pedigreed, genotyped colony of vervets for use as a national resource for research on genetic contributions to faiomedical traits; d) provide training and information on the clinical care and management of vervets to enhance the use of this species in other centers, and e) support the continued use of vervet models for genetic, biobehavioral and neurobiological research, and the development of new vervet models for research in obesity, diabetes and metabolic syndrome. Two cores have been organized to accomplish these aims. The Animal Resources Core will manage the animal care and breeding program, maintain the colony record system, disseminate information on husbandry and clinical characteristics of vervet monkeys, and train veterinarians in the use of vervets for biomedical research. The research component of the Animal Resources Core will focus on increasing infant viability. The Genetics and Biobehavioral Core will provide access for local and national investigators to use the multigenerational VRC pedigree and extensive database of genetic and biobehavioral information available on individual animals, and will provide statistical genetics support for outside investigators to use this resource to find genes that influence biomedical traits. The research component of the Genetics and Biobehavioral Core will contribute to the development of the vervet as a model for obesity, diabetes and metabolic syndrome. These efforts will generate critical information and provide access to animals and research opportunities that will expand the use of the vervet as an alternative nonhuman primate model for the study of human diseases and disorder

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Material Resource Grants (P40)
Project #
5P40RR019963-02
Application #
7392029
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2006-07-01
Project End
2007-06-30
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
2
Fiscal Year
2006
Total Cost
$544,361
Indirect Cost
Name
University of California Los Angeles
Department
Psychiatry
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Chen, Jason A; Fears, Scott C; Jasinska, Anna J et al. (2018) Neurodegenerative disease biomarkers A?1-40, A?1-42, tau, and p-tau181 in the vervet monkey cerebrospinal fluid: Relation to normal aging, genetic influences, and cerebral amyloid angiopathy. Brain Behav 8:e00903
Schmitt, C A; Service, S K; Jasinska, A J et al. (2018) Obesity and obesogenic growth are both highly heritable and modified by diet in a nonhuman primate model, the African green monkey (Chlorocebus aethiops sabaeus). Int J Obes (Lond) 42:765-774
Jasinska, Anna J; Zelaya, Ivette; Service, Susan K et al. (2017) Genetic variation and gene expression across multiple tissues and developmental stages in a nonhuman primate. Nat Genet 49:1714-1721
Tyrrell, Daniel J; Bharadwaj, Manish S; Jorgensen, Matthew J et al. (2016) Blood cell respirometry is associated with skeletal and cardiac muscle bioenergetics: Implications for a minimally invasive biomarker of mitochondrial health. Redox Biol 10:65-77
Morales-Corraliza, Jose; Wong, Harrison; Mazzella, Matthew J et al. (2016) Brain-Wide Insulin Resistance, Tau Phosphorylation Changes, and Hippocampal Neprilysin and Amyloid-? Alterations in a Monkey Model of Type 1 Diabetes. J Neurosci 36:4248-58
Miller, Leslie R; Jorgensen, Matthew J; Kaplan, Jay R et al. (2016) Alterations in levels and ratios of n-3 and n-6 polyunsaturated fatty acids in the temporal cortex and liver of vervet monkeys from birth to early adulthood. Physiol Behav 156:71-8
Kuokkanen, Satu; Polotsky, Alex J; Chosich, Justin et al. (2016) Corpus luteum as a novel target of weight changes that contribute to impaired female reproductive physiology and function. Syst Biol Reprod Med 62:227-42
Bradford, Andrew P; Jones, Kenneth; Kechris, Katerina et al. (2015) Joint MiRNA/mRNA expression profiling reveals changes consistent with development of dysfunctional corpus luteum after weight gain. PLoS One 10:e0135163
Warren, Wesley C; Jasinska, Anna J; García-Pérez, Raquel et al. (2015) The genome of the vervet (Chlorocebus aethiops sabaeus). Genome Res 25:1921-33
Santago 2nd, Anthony C; Plate, Johannes F; Shively, Carol A et al. (2015) Age-related structural changes in upper extremity muscle tissue in a nonhuman primate model. J Shoulder Elbow Surg 24:1660-8

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