The Tissue Engineering Resource Center (TERC) continues to be grounded in strong foundational work on advanced biomaterials and bioreactor systems, while Technology & Research Development Projects (T&RD) have evolved along with the significant scientific and technological progress made by the Center and its many collaborators and associates.At its inception, the Center focus of the TERC research was on functional tissue engineering and regenerative medicine, through the integration of the key elements - cells, scaffolds and bioreactos, via a systems approach. In 2008, the Center was renewed for an additional five years of funding support With that renewal, the Center continue to build upon its core research to renew and refine the biomaterials, bioreactors and imaging tools while expanding its research portfolio to include more complex tissues, and more sophisticated data acquisition and control strategies. Great strides have been made toward this goal during the past eight years. Tissue engineering and regenerative medicie continue to rely on advances at the fundamental level, while supporting clinical and industrial effrts with significant impact on human health. As we look to the next five years, TERC is uniquely positined to help advance the field precisely because it maintains a core research program in the fundamental of tissue engineering (stem cell biology, tissue biomechanics, bioreactor design, biomaterials development, integration with imaging), while pushing the field forward with preclinical studies, translation activities, development of platform technologies, and disease modeling. Our research ha spawned collaborative projects, service projects, and many other opportunities that feed into our fundamental research. As we continue to develop more complex and customized biomaterial and bioreactor systems, we initiate collaborations in new tissue types and disease states. The lessons learned are expected to further strengthen the foundational research with new demands on our systems. This research feedback loop has resulted in significant advances and new directions for th Center while maintaining solid foundational work

Public Health Relevance

Tissue Engineering continues to represent a significant potential for biomedical advances. The TERC continues to support the Tissue Engineering Field in the goal of developing functional tissue grafts to improve the clinical outcomes for tissu grafting, disease modeling, and a better fundamental understanding of the engineering of biological systems.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Biotechnology Resource Grants (P41)
Project #
5P41EB002520-12
Application #
8890834
Study Section
Special Emphasis Panel (ZEB1-OSR-D (J2))
Program Officer
Hunziker, Rosemarie
Project Start
2003-09-01
Project End
2019-07-31
Budget Start
2015-08-01
Budget End
2016-07-31
Support Year
12
Fiscal Year
2015
Total Cost
$1,243,616
Indirect Cost
$213,848
Name
Tufts University
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
073134835
City
Medford
State
MA
Country
United States
Zip Code
02155
Huang, Wenwen; Ling, Shengjie; Li, Chunmei et al. (2018) Silkworm silk-based materials and devices generated using bio-nanotechnology. Chem Soc Rev 47:6486-6504
Ronaldson-Bouchard, Kacey; Ma, Stephen P; Yeager, Keith et al. (2018) Advanced maturation of human cardiac tissue grown from pluripotent stem cells. Nature 556:239-243
Marturano-Kruik, Alessandro; Nava, Michele Maria; Yeager, Keith et al. (2018) Human bone perivascular niche-on-a-chip for studying metastatic colonization. Proc Natl Acad Sci U S A 115:1256-1261
Algarrahi, Khalid; Affas, Saif; Sack, Bryan S et al. (2018) Repair of injured urethras with silk fibroin scaffolds in a rabbit model of onlay urethroplasty. J Surg Res 229:192-199
Algarrahi, Khalid; Franck, Debra; Savarino, Alyssa et al. (2018) Bilayer silk fibroin grafts support functional oesophageal repair in a rodent model of caustic injury. J Tissue Eng Regen Med 12:e1068-e1075
Chen, Timothy; Vunjak-Novakovic, Gordana (2018) In vitro Models of Ischemia-Reperfusion Injury. Regen Eng Transl Med 4:142-153
Wobma, Holly M; Tamargo, Manuel A; Goeta, Shahar et al. (2018) The influence of hypoxia and IFN-? on the proteome and metabolome of therapeutic mesenchymal stem cells. Biomaterials 167:226-234
Ling, Shengjie; Wang, Qi; Zhang, Dong et al. (2018) Integration of stiff graphene and tough silk for the design and fabrication of versatile electronic materials. Adv Funct Mater 28:
Dinjaski, Nina; Huang, Wenwen; Kaplan, David L (2018) Recursive Directional Ligation Approach for Cloning Recombinant Spider Silks. Methods Mol Biol 1777:181-192
Liu, Bohao; Lee, Benjamin W; Nakanishi, Koki et al. (2018) Cardiac recovery via extended cell-free delivery of extracellular vesicles secreted by cardiomyocytes derived from induced pluripotent stem cells. Nat Biomed Eng 2:293-303

Showing the most recent 10 out of 610 publications