Abstract

In the MMT core, focused laser beams are used to achieve high-resolution imaging and to perform precisely controlled micro-manipulations of biological tissues in situ and in vivo. This core includes confocal and nonlinear optical microscopy technologies, optical tweezers and advanced micro-beam techniques. During previous LAMMP funding cycles, the MMT core has made many pivotal contributions to the field of laser-based microscopy, and has broken new ground in applying these technologies to relevant biomedical problems. In the current LAMMP renewal, we continue to push laser microscopy techniques for addressing pertinent questions in cell and tissue biology.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Biotechnology Resource Grants (P41)
Project #
5P41EB015890-38
Application #
9480311
Study Section
Special Emphasis Panel (ZEB1-OSR-C (J1)P)
Program Officer
Shabestari, Behrouz
Project Start
Project End
2019-03-31
Budget Start
2017-04-01
Budget End
2018-03-31
Support Year
38
Fiscal Year
2017
Total Cost
$149,391
Indirect Cost
$52,698

  Institution

Name
University of California Irvine
Department
Type
Domestic Higher Education
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92617

  Publications

Lin, Jessica; Saknite, Inga; Valdebran, Manuel et al. (2018) Feature characterization of scarring and non-scarring types of alopecia by multiphoton microscopy. Lasers Surg Med :
Verdel, Nina; Lentsch, Griffin; Balu, Mihaela et al. (2018) Noninvasive assessment of skin structure by combined photothermal radiometry and optical spectroscopy: coregistration with multiphoton microscopy. Appl Opt 57:D117-D122
Hou, Jue; Williams, Joshua; Botvinick, Elliot L et al. (2018) Visualization of Breast Cancer Metabolism Using Multimodal Nonlinear Optical Microscopy of Cellular Lipids and Redox State. Cancer Res 78:2503-2512
Thorson, Todd J; Botvinick, Elliot L; Mohraz, Ali (2018) Composite bijel-templated hydrogels for cell delivery. ACS Biomater Sci Eng 4:587-594
Hanninen, Adam M; Prince, Richard C; Ramos, Raul et al. (2018) High-resolution infrared imaging of biological samples with third-order sum-frequency generation microscopy. Biomed Opt Express 9:4807-4817
Saidian, Mayer; Lakey, Jonathan R T; Ponticorvo, Adrien et al. (2018) Characterisation of impaired wound healing in a preclinical model of induced diabetes using wide-field imaging and conventional immunohistochemistry assays. Int Wound J :
Horan, Sean T; Gardner, Adam R; Saager, Rolf et al. (2018) Recovery of layered tissue optical properties from spatial frequency-domain spectroscopy and a deterministic radiative transport solver. J Biomed Opt 24:1-11
Lentsch, Griffin; Balu, Mihaela; Koenig, Karsten et al. (2018) In vivo multiphoton microscopy of scabies. JAAD Case Rep 4:985-987
Saager, Rolf B; Baldado, Melissa L; Rowland, Rebecca A et al. (2018) Method using in vivo quantitative spectroscopy to guide design and optimization of low-cost, compact clinical imaging devices: emulation and evaluation of multispectral imaging systems. J Biomed Opt 23:1-12
Kim, Chang Soo; Ingato, Dominique; Wilder-Smith, Petra et al. (2018) Stimuli-disassembling gold nanoclusters for diagnosis of early stage oral cancer by optical coherence tomography. Nano Converg 5:3

Showing the most recent 10 out of 306 publications