Abstract

In the MMT core, focused laser beams are used to achieve high-resolution imaging and to perform precisely controlled micro-manipulations of biological tissues in situ and in vivo. This core includes confocal and nonlinear optical microscopy technologies, optical tweezers and advanced micro-beam techniques. During previous LAMMP funding cycles, the MMT core has made many pivotal contributions to the field of laser-based microscopy, and has broken new ground in applying these technologies to relevant biomedical problems. In the current LAMMP renewal, we continue to push laser microscopy techniques for addressing pertinent questions in cell and tissue biology.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Biotechnology Resource Grants (P41)
Project #
5P41EB015890-38
Application #
9480311
Study Section
Special Emphasis Panel (ZEB1-OSR-C (J1)P)
Program Officer
Shabestari, Behrouz
Project Start
Project End
2019-03-31
Budget Start
2017-04-01
Budget End
2018-03-31
Support Year
38
Fiscal Year
2017
Total Cost
$149,391
Indirect Cost
$52,698

  Institution

Name
University of California Irvine
Department
Type
Domestic Higher Education
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92617

  Publications

Lentsch, Griffin; Balu, Mihaela; Williams, Joshua et al. (2018) In vivo multiphoton microscopy of melasma. Pigment Cell Melanoma Res :
Moon, Sucbei; Chen, Zhongping (2018) Phase-stability optimization of swept-source optical coherence tomography. Biomed Opt Express 9:5280-5295
Lertsakdadet, Ben; Yang, Bruce Y; Dunn, Cody E et al. (2018) Correcting for motion artifact in handheld laser speckle images. J Biomed Opt 23:1-7
Kim, Seong M; Nguyen, Tricia T; Ravi, Archna et al. (2018) PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells. Cancer Discov 8:866-883
Li, Yan; Chen, Zhongping (2018) Multimodal Intravascular Photoacoustic and Ultrasound Imaging. Biomed Eng Lett 8:193-201
Ponticorvo, Adrien; Rowland, Rebecca; Baldado, Melissa et al. (2018) Evaluating clinical observation versus Spatial Frequency Domain Imaging (SFDI), Laser Speckle Imaging (LSI) and thermal imaging for the assessment of burn depth. Burns :
Lin, Jessica; Saknite, Inga; Valdebran, Manuel et al. (2018) Feature characterization of scarring and non-scarring types of alopecia by multiphoton microscopy. Lasers Surg Med :
Verdel, Nina; Lentsch, Griffin; Balu, Mihaela et al. (2018) Noninvasive assessment of skin structure by combined photothermal radiometry and optical spectroscopy: coregistration with multiphoton microscopy. Appl Opt 57:D117-D122
Hou, Jue; Williams, Joshua; Botvinick, Elliot L et al. (2018) Visualization of Breast Cancer Metabolism Using Multimodal Nonlinear Optical Microscopy of Cellular Lipids and Redox State. Cancer Res 78:2503-2512
Thorson, Todd J; Botvinick, Elliot L; Mohraz, Ali (2018) Composite bijel-templated hydrogels for cell delivery. ACS Biomater Sci Eng 4:587-594

Showing the most recent 10 out of 306 publications