The Center for Advanced Imaging Innovation and Research (CAI2R) combines three areas of novel and high-impact imaging technology development with a unique new model for interdepartmental and academic-industrial collaboration aimed at translating that technology rapidly and effectively into clinical practice. The technologies to be developed center around a new paradigm of rapid, continuous, and comprehensive data acquisition, together with flexible image reconstruction, which will affect and connect multiple imaging modalities, including magnetic resonance imaging (MRI) and Positron Emission Tomography (PET). Technology Research and Development (TR&D) project #1 aims at a new use of time in imaging, deploying leading-edge methods of rapid image acquisition and advanced image reconstruction to replace traditional complex, targeted, and inefficient imaging protocols with simple, comprehensive, volumetric acquisitions that contain rich information about multiple complementary contrasts and diverse dynamics. TR&D #2 envisions new and improved uses for radiofrequency (RF) fields, providing new tools for RF design, safety and control in MRI, and expanding the reach of the rapid continuous acquisition approach developed in TR&D #1 to high-performance high-field applications. TR&D #3 is addressed at new uses of simultaneity, advancing the fundamental capabilities of MR and PET through synergistic simultaneous acquisition and joint reconstruction. Our Center has a unique and explicit translational focus, which is reflected in the day-to-day operation of TR&D projects as well as in the topics of Collaborative Projects (CPs) and Service Projects (SPs), which are focused on three general areas of high public health impact: cancer, musculoskeletal disease, and neurologic disease. In keeping with this translational emphasis, CAI2R is also be driven by a novel collaboration model in which basic scientists, clinicians, and industry developers sit down together regularly at the scanners and in reading rooms for interactive technology development and assessment. This interdisciplinary collaboration model also informs our Training activities, many of which are addressed at the formation and operation of successful translational research teams. Meanwhile, with early involvement of clinical stakeholders and industry partners, we aim to make CAI2R technologies widely available for clinical and research use. Our broadest goal in CAI2R is to change the paradigms of data acquisition, image reconstruction, and day-to-day scanning for MR and PET, for the advancement of biomedical knowledge and for the benefit of patients and the physicians who care for them.
The Center for Advanced Imaging Innovation and Research (CAI2R) develops novel imaging techniques and technologies for the improved diagnosis and management of cancer, musculoskeletal disease, and neurological disease. By exploiting connections between imaging modalities such as MRI and PET, we aim to advance the fundamental capabilities of each, so as to expand biomedical knowledge and improve the care of patients.
| Bertrand, Anne; Baron, Maria; Hoang, Dung M et al. (2018) In Vivo Evaluation of Neuronal Transport in Murine Models of Neurodegeneration Using Manganese-Enhanced MRI. Methods Mol Biol 1779:527-541 |
| Xia, Ding; Lee, Jae-Seung; Regatte, Ravinder R (2018) Quadrupolar jump-and-return pulse sequence for fluid-suppressed sodium MRI of the knee joint at 7T. Magn Reson Med 80:641-647 |
| Nunes Neto, Lucidio P; Madelin, Guillaume; Sood, Terlika Pandit et al. (2018) Quantitative sodium imaging and gliomas: a feasibility study. Neuroradiology 60:795-802 |
| Sharafi, Azadeh; Chang, Gregory; Regatte, Ravinder R (2018) Biexponential T2 relaxation estimation of human knee cartilage in vivo at 3T. J Magn Reson Imaging 47:809-819 |
| Chen, Gang; Zhang, Bei; Cloos, Martijn A et al. (2018) A highly decoupled transmit-receive array design with triangular elements at 7T. Magn Reson Med 80:2267-2274 |
| Assländer, Jakob; Cloos, Martijn A; Knoll, Florian et al. (2018) Low rank alternating direction method of multipliers reconstruction for MR fingerprinting. Magn Reson Med 79:83-96 |
| Alon, Leeor; Lattanzi, Riccardo; Lakshmanan, Karthik et al. (2018) Transverse slot antennas for high field MRI. Magn Reson Med 80:1233-1242 |
| Feng, Li; Delacoste, Jean; Smith, David et al. (2018) Simultaneous Evaluation of Lung Anatomy and Ventilation Using 4D Respiratory-Motion-Resolved Ultrashort Echo Time Sparse MRI. J Magn Reson Imaging : |
| Liu, Saifeng; Brisset, Jean-Christophe; Hu, Jiani et al. (2018) Susceptibility weighted imaging and quantitative susceptibility mapping of the cerebral vasculature using ferumoxytol. J Magn Reson Imaging 47:621-633 |
| Leithner, Doris; Moy, Linda; Morris, Elizabeth A et al. (2018) Abbreviated MRI of the Breast: Does It Provide Value? J Magn Reson Imaging : |
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