Abstract

We have partnered with 10 outside laboratories from across the United States to form driving biomedical projects (DBPs) for our technology development efforts. These projects represent important and cutting edge research problems that cannot presently be solved with current technologies. The DBPs provide a quantifiable measure of our progress in our Technology Research and Development cores. These DBPs will provide an opportunity to demonstrate and refine our resource technologies. The DBPs are test-bed projects and require significant iterative back and forth between the TR&D personnel and the collaborating lab. Thus, each DBP was carefully selected based on a combination of the biological importance of the project, it providing a challenge to drive a specific TR&D, a working relationship of the collaborating laboratory with a co-investigator in the Yeast Resource Center, and willingness to work through failures of emerging technologies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Biotechnology Resource Grants (P41)
Project #
2P41GM103533-21
Application #
9208074
Study Section
Special Emphasis Panel (ZRG1)
Project Start
1997-09-30
Project End
2022-03-31
Budget Start
2017-01-01
Budget End
2017-12-31
Support Year
21
Fiscal Year
2017
Total Cost
Indirect Cost

  Institution

Name
University of Washington
Department
Biochemistry
Type
Schools of Medicine
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Searle, Brian C; Pino, Lindsay K; Egertson, Jarrett D et al. (2018) Chromatogram libraries improve peptide detection and quantification by data independent acquisition mass spectrometry. Nat Commun 9:5128
Payea, Matthew J; Sloma, Michael F; Kon, Yoshiko et al. (2018) Widespread temperature sensitivity and tRNA decay due to mutations in a yeast tRNA. RNA 24:410-422
Seixas, Adriana; Alzugaray, María Fernanda; Tirloni, Lucas et al. (2018) Expression profile of Rhipicephalus microplus vitellogenin receptor during oogenesis. Ticks Tick Borne Dis 9:72-81
Luan, Qing; Zelter, Alex; MacCoss, Michael J et al. (2018) Identification of Wiskott-Aldrich syndrome protein (WASP) binding sites on the branched actin filament nucleator Arp2/3 complex. Proc Natl Acad Sci U S A 115:E1409-E1418
Smukowski Heil, Caiti; Burton, Joshua N; Liachko, Ivan et al. (2018) Identification of a novel interspecific hybrid yeast from a metagenomic spontaneously inoculated beer sample using Hi-C. Yeast 35:71-84
Ziegler, Yvonne S; Moresco, James J; Tu, Patricia G et al. (2018) Proteomic analysis identifies highly expressed plasma membrane proteins for detection and therapeutic targeting of specific breast cancer subtypes. Clin Proteomics 15:30
Nishimura, Noriyuki; Tsuchiya, Wataru; Moresco, James J et al. (2018) Control of seed dormancy and germination by DOG1-AHG1 PP2C phosphatase complex via binding to heme. Nat Commun 9:2132
McClatchy, Daniel B; Ma, Yuanhui; Liem, David A et al. (2018) Quantitative temporal analysis of protein dynamics in cardiac remodeling. J Mol Cell Cardiol 121:163-172
Starita, Lea M; Islam, Muhtadi M; Banerjee, Tapahsama et al. (2018) A Multiplex Homology-Directed DNA Repair Assay Reveals the Impact of More Than 1,000 BRCA1 Missense Substitution Variants on Protein Function. Am J Hum Genet 103:498-508
Wang, Zheng; Wu, Catherine; Aslanian, Aaron et al. (2018) Defective RNA polymerase III is negatively regulated by the SUMO-Ubiquitin-Cdc48 pathway. Elife 7:

Showing the most recent 10 out of 372 publications