The ?Center on Macromolecular Dynamics by NMR Spectroscopy? (CoMD/NMR) will install the world's first field-cycling shuttle system for an 800 MHz NMR spectrometer, to be sited at the New York Structural Biology Center. This instrument will enable applications of relaxometry to DBPs, to significantly increase knowledge of the relevant spectral density functions and therefore allow much more detailed investigations of macromolecular conformational dynamics. Relaxometry is a technique in which a sample is polarized at high static magnetic field, then physically moved to low field for a relaxation period, and subsequently returned to high field for detection. Activities in this TR&D will include evaluation of alternative shuttle designs, development of novel experimental strategies for use of the shuttle probe, and iterative development and validation of analysis approaches to interpret relaxometric data for the DBPs.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Biotechnology Resource Grants (P41)
Project #
5P41GM118302-04
Application #
9967026
Study Section
Special Emphasis Panel (ZRG1)
Project Start
Project End
Budget Start
2020-06-01
Budget End
2021-05-31
Support Year
4
Fiscal Year
2020
Total Cost
Indirect Cost
Name
New York Structural Biology Center
Department
Type
DUNS #
011191520
City
New York
State
NY
Country
United States
Zip Code
10027
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