We are investigating the features of glucagon receptor recognition that leads to transduction of the physiological message triggered by the peptide hormone glucagon. This involves using solid phase peptide synthesis to study the effects of structural modification on the binding affinity and activity of the hormone. Our studies should lead to the discovery of glucagon antagonists that may potentially be used for the management of diabetes mellitus.
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| Zhong, Yu; Morris, Deanna H; Jin, Lin et al. (2014) Nrbf2 protein suppresses autophagy by modulating Atg14L protein-containing Beclin 1-Vps34 complex architecture and reducing intracellular phosphatidylinositol-3 phosphate levels. J Biol Chem 289:26021-37 |
| Indiani, Chiara; O'Donnell, Mike (2013) A proposal: Source of single strand DNA that elicits the SOS response. Front Biosci (Landmark Ed) 18:312-23 |
| Di Virgilio, Michela; Callen, Elsa; Yamane, Arito et al. (2013) Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching. Science 339:711-5 |
Showing the most recent 10 out of 67 publications
