This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. One of our studies involves finding out how innate immune responses recognize antigen and how this relate to the marginal zone of the spleen. Our group has found that the Marginal zone B-cells are required for a T-cell independent type II response whereas they were not required for responses to T-cell dependent and T-cell independent type I Ag's. We are currently studying how Ag deposits in the Marginal zone and which cells that are involved in the reaction. We are also interested in the signals required to generate this specific structure, since cells from the marginal zone can also give rise to specific forms of cancer. Thus, studying how cells in this region are activated and regulated is of importance not only for immunity towards pathogens but also for the understanding of mechanisms underlying formation of cancer.
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