This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Development of on-surface digestion protocol. Initial studies towards digestion of protein complexes on the polycarbonate surface of MALDI compact disc targets, with the goal of minimizing selective loss of phosphopeptides during sample handling and preparation. Wide window scanning for phosphorylation site detection. In collaboration with Derek McLaughlin, formerly in this lab, studies were undertaken to evaluate the use of wide (up to 100 m/z) isolation window for detection of phosphorylated peptides using MALDI-ion trap mass spectrometry. Development of chemical means for quantitating changes in the level of phosphorylation at particular sites in proteins from the brains of mi
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