This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The algorithm was written as a statistical tool for genomic and proteomic analysis. For instance, using the Saccharomyces cerevisiae genome, the program can generate a distribution of peptides produced by a user-defined enzymatic or chemical cleavage of the proteins or DNA. The output of the program can be configured to display the distribution in number of residues/nucleotides or in mass. This approach can be useful in planning proteolysis experiments of whole cell lysates and in designing separation and purification strategies of the polypeptides thus generated. The algorithm is complete, but still requires a graphical program to create the graphics for the statistical distribution. A graphical user interface (GUI) is being written for this piece of software to allow for immediate visualization of the statistical distribution without the need to export the data to an ancillary piece of software.
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