This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.The Allis laboratory at The Rockefeller University studies how post-translational modifications on histones affect the biology of chromatin. In this regard, we are working towards a complete map of post-translational modifications on histone H3 from Schizosaccharomyces pombe. Dr. Tanny has isolated H3 via column chromatography. We are using a combination of single and tandem mass spectrometry to identify the sites and types of modifications. Current efforts on this project: 1) finish mapping the post-translational modifications, and 2) compare the post-translational modifications from asynchronous growth to that at certain stages of growth such as mitosis.
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| Zhong, Yu; Morris, Deanna H; Jin, Lin et al. (2014) Nrbf2 protein suppresses autophagy by modulating Atg14L protein-containing Beclin 1-Vps34 complex architecture and reducing intracellular phosphatidylinositol-3 phosphate levels. J Biol Chem 289:26021-37 |
| Indiani, Chiara; O'Donnell, Mike (2013) A proposal: Source of single strand DNA that elicits the SOS response. Front Biosci (Landmark Ed) 18:312-23 |
| Di Virgilio, Michela; Callen, Elsa; Yamane, Arito et al. (2013) Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching. Science 339:711-5 |
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