Abstract

This research application of the Washington University Mass Spectrometry Resource plans: 1) To continue to provide a wide range of low resolution GCMS, and high resolution mass spectrometry services to biomedical investigators who request this assistance. 2) To continue to provide expert technical assistance, analytical services, and interpretive advice on high precision GCMS selected ion monitoring quantitation of substrate content and stable isotope enrichment in physiological samples. 3) To provide isotope ratio mass spectrometry (IRMS) services for precise measurement of hydrogen, carbon, nitrogen, and oxygen isotopes in end products of endogenous substrate metabolism occurring as a result of stable isotope tracer experiments in man. 4) To provide GC/Combusion/IRMS analyses of the highly diluted carbon isotopic enrichment values occurring in human precursor-product tracer studies to facilitate application of these studies to clinical research problems of biomedical importance. 5) To provide LCMS, CF-FAB and SCF-MS services for biochemical substrates not amenable to GCMS analysis. 6) To provide fast atom bombardment and plasma desorption ionization mass spectrometry for analysis of biopolymers of high molecular weight. 7) To make these facilities available for use by qualified investigators at the loca, regional, national and international levels.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR000954-16
Application #
3103713
Study Section
Special Emphasis Panel (SSS (C))
Project Start
1975-06-01
Project End
1994-02-28
Budget Start
1992-03-16
Budget End
1993-02-28
Support Year
16
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
Washington University
Department
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130

  Publications

Yue, Xuyi; Dhavale, Dhruva D; Li, Junfeng et al. (2018) Design, synthesis, and in vitro evaluation of quinolinyl analogues for ?-synuclein aggregation. Bioorg Med Chem Lett 28:1011-1019
Ohlemacher, Shannon I; Giblin, Daryl E; d'Avignon, D André et al. (2017) Enterobacteria secrete an inhibitor of Pseudomonas virulence during clinical bacteriuria. J Clin Invest 127:4018-4030
Lin, Xiaobo; Racette, Susan B; Ma, Lina et al. (2017) Endogenous Cholesterol Excretion Is Negatively Associated With Carotid Intima-Media Thickness in Humans. Arterioscler Thromb Vasc Biol 37:2364-2369
Ovod, Vitaliy; Ramsey, Kara N; Mawuenyega, Kwasi G et al. (2017) Amyloid ? concentrations and stable isotope labeling kinetics of human plasma specific to central nervous system amyloidosis. Alzheimers Dement 13:841-849
Cade, W Todd; Levy, Philip T; Tinius, Rachel A et al. (2017) Markers of maternal and infant metabolism are associated with ventricular dysfunction in infants of obese women with type 2 diabetes. Pediatr Res 82:768-775
Lucey, Brendan P; Mawuenyega, Kwasi G; Patterson, Bruce W et al. (2017) Associations Between ?-Amyloid Kinetics and the ?-Amyloid Diurnal Pattern in the Central Nervous System. JAMA Neurol 74:207-215
Wei, Xiaochao; Song, Haowei; Yin, Li et al. (2016) Fatty acid synthesis configures the plasma membrane for inflammation in diabetes. Nature 539:294-298
Shields-Cutler, Robin R; Crowley, Jan R; Miller, Connelly D et al. (2016) Human Metabolome-derived Cofactors Are Required for the Antibacterial Activity of Siderocalin in Urine. J Biol Chem 291:25901-25910
Mertins, Philipp; Mani, D R; Ruggles, Kelly V et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534:55-62
Murata, Takahiro; Dietrich, Hans H; Horiuchi, Tetsuyoshi et al. (2016) Mechanisms of magnesium-induced vasodilation in cerebral penetrating arterioles. Neurosci Res 107:57-62

Showing the most recent 10 out of 696 publications