Whole body protein kinetics were investigated in 13 subjects, children with edematous malnutrition (EM) and acute infection and compared with 14 controls, children with EM early in recovery with a primed, constant infusion of 13C-leucine and 15N2-urea in the fasted state. Calculations of rates of whole body protein synthesis, and breakdown were made using isotopic enrichments of serum 13C-leucine and the rate of urea turnover was used to estimate the rate of leucine oxidation. Protein synthesis and protein breakdown rates were lower in subjects than in controls (97 + 30 vs 153 + 67, p

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR000954-20
Application #
5221825
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
20
Fiscal Year
1996
Total Cost
Indirect Cost
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