An efficient one-pot synthetic route to JM3100 (AMD3100), a highly potent inhibitor of HIV multiplication entering clinical trials, is reported based on temporary protection of the cyclam followed by reaction with P,P'-dibromoxylene and deprotection to give the bis-cyclam. This route can readily be adapted to the production of analogs of JM3100.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR000954-25
Application #
6486698
Study Section
Project Start
2001-08-01
Project End
2002-07-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
25
Fiscal Year
2001
Total Cost
$157,506
Indirect Cost
Name
Washington University
Department
Type
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
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