This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Measuring insulin sensitivity in presence of physiological changes in glucose and insulin concentrations, e.g. during a meal or OGTT, is important to better understand insulin resistance in a variety of metabolic conditions. Recently two oral minimal models have been proposed to measure overall insulin sensitivity (SI) and its selective effect on glucose disposal (SI*) from oral tests. SI and SI* have been successfully validated against multiple tracer meal estimates, but validation against euglycemic hyperinsulinemic clamp estimates is lacking. Here we do so in 21 subjects, who underwent both a multiple tracer OGTT and a labeled euglycemic hyperinsulinemic clamp. Correlation between minimal model SI, SI* and corresponding clamp estimates SIclamp, SI* clamp was satisfactory, respectively R=0.81, p<0.001 and R=0.71, p<0.001. SI was significantly lower than SIclamp (8.08 0.89 vs 13.66 1.69 10-4 dl/kg/min per U/ml, p = 0.0002), while SI* and SI* clamp were very similar (8.17 1.59 vs 8.84 1.39 10-4 dl/kg/min per U/ml, p = 0.52). These results add credibility to the oral minimal model method as a reliable physiological tool to estimate SI and SI* , also in large scale clinical trials.
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