This subproject is one of many research subprojects utilizing theresources provided by a Center grant funded by NIH/NCRR. The subproject andinvestigator (PI) may have received primary funding from another NIH source,and thus could be represented in other CRISP entries. The institution listed isfor the Center, which is not necessarily the institution for the investigator.What is the function of the novel class-I-like protein, MR1, in regulating mucosal immunity? MR1 is highly conserved MHC-I-like protein in mammals, that activates a unique population of T cells with an invariant T cell receptor. Interestingly the development of these MR1 activated T cells is dependent upon the commensal flora of the gut. Our experiments are using biochemical, cellular, transgenic and crystallographic approaches to determine the structure and function of MR1 proteins. MS is one of the approaches that represents a cross-campus and cross-resource collaboration.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR000954-30
Application #
7597611
Study Section
Special Emphasis Panel (ZRG1-BPC-H (40))
Project Start
2007-02-01
Project End
2008-01-31
Budget Start
2007-02-01
Budget End
2008-01-31
Support Year
30
Fiscal Year
2007
Total Cost
$1,695
Indirect Cost
Name
Washington University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
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