The National Biomedical ESR Center, established in 1976 at the Medical College of Wisconsin is the largest biomedical ESR facility in th world with balanced separately funded programs of health related research in the major branches of the field: spin labels, transition metals, and free radicals. During the previous five year funding period, two notable advances in Technological Development occurred that form the basis of much of the renewal. Multiquantum ESR spectroscopy, the first advance, has the potential of dramatically changing and improving the basic technology. New approaches to computer-aided ESR, the second advance, including Sensitivity Analysis and Pseudomodulation strengthen the application of modern information theory to ESR spectroscopy. Other developments of the Center also impact on the structure of the proposal including multifrequency ESR, loop gap resonators, and improved microwave bridges. Specifically, five Technological Research and Development projects are proposed: (1) Construction of a state-of-the-art X-band spectrometer with multiquantum capability, (2) Further studies on multiquantum ESR spectroscopy, (3) loop gap resonator design (4) computer-aided ESR and (5) development and application of a rapid-mixing-rapid-scan accessory. The Center has grown during the past five years following its move to a new building and a more than double increase in the number of graduate students. This growth presents new opportunities, and the proposal requests a substantial increase in level of support. The goals of the center are (a) to be innovative in developing new ESR instrumental modalities, (b) to make available at a national level advanced ESR instruments and expertise, and (c) to carry out separately funded health research in selected areas using ESR spectroscopy.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR001008-20
Application #
2281416
Study Section
Special Emphasis Panel (SSS (C3))
Project Start
1976-05-01
Project End
1997-02-28
Budget Start
1995-03-02
Budget End
1996-02-29
Support Year
20
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Medical College of Wisconsin
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
073134603
City
Milwaukee
State
WI
Country
United States
Zip Code
53226
Mao, Li; Liu, Yu-Xiang; Huang, Chun-Hua et al. (2015) Intrinsic Chemiluminescence Generation during Advanced Oxidation of Persistent Halogenated Aromatic Carcinogens. Environ Sci Technol 49:7940-7
Shan, Guo-Qiang; Yu, Ao; Zhao, Chuan-Fang et al. (2015) A combined experimental and computational investigation on the unusual molecular mechanism of the Lossen rearrangement reaction activated by carcinogenic halogenated quinones. J Org Chem 80:180-9
Li, Yan; Huang, Chun-Hua; Liu, Yu-Xiang et al. (2014) Detoxifying polyhalogenated catechols through a copper-chelating agent by forming stable and redox-inactive hydrogen-bonded complexes with an unusual perpendicular structure. Chemistry 20:13028-33
Shao, Jie; Huang, Chun-Hua; Kalyanaraman, Balaraman et al. (2013) Potent methyl oxidation of 5-methyl-2'-deoxycytidine by halogenated quinoid carcinogens and hydrogen peroxide via a metal-independent mechanism. Free Radic Biol Med 60:177-82
Sheng, Zhi-Guo; Li, Yan; Fan, Rui-Mei et al. (2013) Lethal synergism between organic and inorganic wood preservatives via formation of an unusual lipophilic ternary complex. Toxicol Appl Pharmacol 266:335-44
Qin, Hao; Huang, Chun-Hua; Mao, Li et al. (2013) Molecular mechanism of metal-independent decomposition of lipid hydroperoxide 13-HPODE by halogenated quinoid carcinogens. Free Radic Biol Med 63:459-66
Huang, Chun-Hua; Shan, Guo-Qiang; Mao, Li et al. (2013) The first purification and unequivocal characterization of the radical form of the carbon-centered quinone ketoxy radical adduct. Chem Commun (Camb) 49:6436-8
Sheng, Zhi-Guo; Huang, Wei; Liu, Yu-Xiang et al. (2013) Ofloxacin induces apoptosis via ?1 integrin-EGFR-Rac1-Nox2 pathway in microencapsulated chondrocytes. Toxicol Appl Pharmacol 267:74-87
Sheng, Zhi-Guo; Huang, Wei; Liu, Yu-Xiang et al. (2013) Bisphenol A at a low concentration boosts mouse spermatogonial cell proliferation by inducing the G protein-coupled receptor 30 expression. Toxicol Appl Pharmacol 267:88-94
Liddle, Brendan J; Wanniarachchi, Sarath; Hewage, Jeewantha S et al. (2012) Electronic communication across diamagnetic metal bridges: a homoleptic gallium(III) complex of a redox-active diarylamido-based ligand and its oxidized derivatives. Inorg Chem 51:12720-8

Showing the most recent 10 out of 368 publications