Using the facilities of the Computer Graphics Laboratory, we are working on modelling the substrate binding sites of new granzyme serine proteases, based on the X-ray crystal structure of rat mast cell chymase II, another serine protease. Knowledge of potential substrates will allow them to be synthesized and tested to determine if the granzyme gene products are active enzymes. These proteases are in cytotoxic granules of killer cells and probably play critical roles in killing of virally infected cells and/or in signalling for inflammation.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Biotechnology Resource Grants (P41)
Project #
5P41RR001081-22
Application #
6119173
Study Section
Project Start
1999-07-01
Project End
2000-06-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
22
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
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