This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The ability to reliably and non-invasively measure the degree of anemia and physiologic status of tissues, as well as the response of these measures to correct anemia with transfusions, could both improve our understanding and definition of true physiologic anemia and allow us to measure the degree of anemia without exacerbating the problem through iatrogenic blood loss. We propose a procedure in this protocol that will quantify functional measures of red blood cell mass and oxygen in neonatal tissues using a non-invasive optical technique: near infrared optical spectroscopy (NIRS).
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