This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Co-registration of near-infrared spectroscopy with MRI imaging provides a unique set of information about tissue physiology and structure. Simultaneous MRI co-registration complements the optical data by providing structural and functional images of the tumor. Using Monte Carlo simulations, the optically sampled volume can be superimposed on the MRI images, showing precisely which tissue structure is visited by photons. MRI data provide complementary functional information on perfusion and water content that can be correlated with the optical measurements. Optical measurements performed on Gd-DTPA enhanced regions indicating edematous tissue status correlate with increasing tissue water fraction. Furthermore, 'viable' tissue as indicated in MR images correlates with decreasing tissue water fraction. In addition, optical spectroscopy has been used to track the oxygenation status of developing tumor. Results are consistent with the transformation of tumor to a necrotic state. Finally, the intratumoral dynamics of indocyanine green and methylene blue dye are measured in-vivo using our optical system.
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